Formation and early morphogenesis of endocardial endothelial precursor cells and the role of endoderm

Developmental Biology
Y Sugi, R R Markwald

Abstract

The formation of endocardial endothelium in quail embryos was investigated using in vivo and in vitro systems. Based on the expression of an quail endothelial marker, QH-1, the initial emergence of endothelial precursor cells in the embryo occurs at stage 7+ (two somites) in the posterior parts of the bilateral heart forming regions. Cells that expressed the QH-1 antigen were mesenchymal and positioned between the mesodermal epithelium of the heart region and the endoderm. By confocal microscopy, an asymmetrical distribution of QH-1 positive cells was observed between the two heart regions: specifically between 7+ and 8-, more precursor cells were seen in the right region than the left. Endothelial precursor cells did not appear outside of the heart forming regions until stage 8- (three somites). Free, mesenchymal-like endothelial precursor cells intrinsic to the heart regions also expressed two extracellular antigens, JB3, a fibrillin-like protein, and cytotactin, both associated with segments of the primary heart tube where endothelial cells "re-transform" back to a mesenchymal phenotype during cardiac cushion tissue formation. Between stages 8 and 9 (four to seven somites), (1) QH-1 positive cells within the heart forming re...Continue Reading

Citations

Oct 22, 2003·Developmental Biology·Yukiko Sugi, Roger R Markwald
Jun 5, 2003·Matrix Biology : Journal of the International Society for Matrix Biology·Richard P ViscontiCharles D Little
Dec 6, 1997·Current Opinion in Genetics & Development·T Mohun, D Sparrow
Aug 3, 2005·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Kersti K LinaskMingda Han
Feb 2, 2011·Cardiovascular Research·Paul R Riley, Nicola Smart
Jun 23, 2004·Development, Growth & Differentiation·Nikolas ZagrisAnastasia Giakoumaki
Apr 26, 2007·Annual Review of Cell and Developmental Biology·Radwan Abu-Issa, Margaret L Kirby
Mar 24, 1998·Annual Review of Medicine·S M Schwartz, C E Murry
Apr 29, 1998·Annual Review of Physiology·H M Sucov
Oct 25, 2008·Circulation Research·Julius AitsebaomoCam Patterson
Aug 29, 2007·PLoS Genetics·Jeroen BussmannStefan Schulte-Merker
Jul 21, 2001·Stem Cells·D L Ramírez-Bergeron, M C Simon
Feb 2, 2016·Biochimica Et Biophysica Acta·Atsushi NakanoNathan J Palpant
Jun 20, 2015·Journal of Cardiovascular Development and Disease·Paige SniderSimon J Conway
Jun 2, 2012·Differentiation; Research in Biological Diversity·Adriana C Gittenberger-de GrootRobert E Poelmann
Apr 19, 2011·Differentiation; Research in Biological Diversity·Katsumi AndoYuji Nakajima
Sep 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·John M GansnerJonathan D Gitlin
May 4, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Daniel M DeLaughterJoey V Barnett
Jun 26, 2003·Differentiation; Research in Biological Diversity·Kyoko Imanaka-YoshidaToshimichi Yoshida
May 11, 1999·Differentiation; Research in Biological Diversity·R Muñoz-ChápuliM González
Aug 6, 1999·Developmental Biology·L MiquerolA Nagy
May 12, 2004·Developmental Biology·Scott R MayAndrew S Peterson
Sep 6, 2005·Developmental Biology·Jikui WangVesa Kaartinen
Aug 15, 2014·Frontiers in Physiology·Kyoko Imanaka-Yoshida, Hiroki Aoki
May 22, 2016·Seminars in Cell & Developmental Biology·Hye Young KimLance A Davidson
Jul 6, 2017·Anatomia, histologia, embryologia·T H Abd-ElhamidA R Sinning
Nov 21, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Y Wei, T Mikawa
Jan 10, 2002·Genesis : the Journal of Genetics and Development·K A MosesR J Schwartz
Jan 9, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T J PooleC M Cox
Apr 22, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Eric B Finkelstein, Thomas J Poole
Jul 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Y NakajimaR R Markwald
Aug 10, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Robert E WeliksonStephen D Hauschka
Feb 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Beerend P HierckRobert E Poelmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.