Formation and enlargement of the paranasal sinuses in normal and cleft lip and palate human fetuses

The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
T D SmithJ S Todhunter

Abstract

Comparisons of paranasal sinus morphology between humans with and without cleft lip and palate (CLP) have yielded conflicting opinions regarding size differences. Although postnatal samples have been investigated, no studies have compared paranasal sinus volumes between cleft and noncleft human fetuses. The nasal cavities of 20 'normal' and 9 CLP human fetuses (8-21 weeks' postmenstrual age) were examined to assess prenatal volumetric changes of the maxillary sinuses, anterior and posterior ethmoidal air cells, and sphenoidal sinuses. Lengths and volumes of right and left maxillary and sphenoidal sinuses were calculated from histologically prepared sections using a computer reconstruction technique, and regression equations were generated to assess the enlargement rates. All paranasal sinuses were found among both normal and CLP specimens in the same locations and in similar age ranges. However, greater shape asymmetry was noted for all sinuses in CLP compared to normal specimens. In the normal sample, results indicated significant (p < .05) correlations between right or left maxillary sinus length (R2 = 0.49, 0.54) and volume (R2 = 0.67, 0.68), and increasing postmenstrual age, but no significant (p > .05) correlations were ob...Continue Reading

References

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Citations

May 22, 2010·Surgical and Radiologic Anatomy : SRA·Rieko AsaumiTakashi Yosue
Oct 26, 2005·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Bo Werner NielsenInger Kjaer
Jan 25, 2008·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·K A CarmodyT D Smith
Nov 16, 2010·International Journal of Oral and Maxillofacial Surgery·R KirmeierN Jakse
Jun 29, 2005·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Timothy D SmithMichael I Siegel
Aug 22, 2015·International Journal of Pediatric Otorhinolaryngology·Omer ErdurSuleyman Kutalmıs Buyuk
Oct 28, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Timothy D SmithAnne M Burrows
Oct 3, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Timothy D SmithMichael I Siegel
Jan 20, 2018·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Omer DemirtasElif Tarim
Feb 12, 2014·The Journal of Craniofacial Surgery·Umit Aksoy OzcanHalil Ibrahim Canter
Nov 24, 2020·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Mariana Latas RodriguesFrancisco Vale

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