Formation and function of the manchette and flagellum during spermatogenesis

Reproduction : the Official Journal of the Society for the Study of Fertility
Mari S Lehti, Anu Sironen

Abstract

The last phase of spermatogenesis involves spermatid elongation (spermiogenesis), where the nucleus is remodeled by chromatin condensation, the excess cytoplasm is removed and the acrosome and sperm tail are formed. Protein transport during spermatid elongation is required for correct formation of the sperm tail and acrosome and shaping of the head. Two microtubular-based protein delivery platforms transport proteins to the developing head and tail: the manchette and the sperm tail axoneme. The manchette is a transient skirt-like structure surrounding the elongating spermatid head and is only present during spermatid elongation. In this review, we consider current understanding of the assembly, disassembly and function of the manchette and the roles of these processes in spermatid head shaping and sperm tail formation. Recent studies have shown that at least some of the structural proteins of the sperm tail are transported through the intra-manchette transport to the basal body at the base of the developing sperm tail and through the intra-flagellar transport to the construction site in the flagellum. This review focuses on the microtubule-based mechanisms involved and the consequences of their disruption in spermatid elongation.

References

Feb 19, 2000·Current Opinion in Cell Biology·B L GoodeG Barnes
Mar 8, 2000·The Journal of Cell Biology·S P GrossE F Wieschaus
Apr 25, 2000·Biology of Reproduction·P M Navolanic, A O Sperry
Sep 13, 2000·Molecular Reproduction and Development·K MochidaA L Kierszenbaum
Nov 10, 2000·Developmental Biology·K MochidaA L Kierszenbaum
Apr 28, 2001·Nature Genetics·C ChoE M Eddy
Jun 1, 2001·Molecular Human Reproduction·I M AdhamW Engel
Jul 27, 2001·Molecular Reproduction and Development·A L Kierszenbaum
Jun 21, 2002·Human Molecular Genetics·Irene Mendoza-LujambioJuergen Neesen
Sep 5, 2002·Molecular Reproduction and Development·Abraham L Kierszenbaum
Jun 5, 2003·Molecular Reproduction and Development·Denise EscalierXin Xu
Sep 18, 2003·The Journal of Biological Chemistry·Karim NayerniaHans-Henning Arnold
Aug 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Zhibing ZhangJerome F Strauss
Feb 11, 2005·Archives of Histology and Cytology·Abraham L Kierszenbaum, Laura L Tres
Feb 11, 2005·Archives of Histology and Cytology·Chizuru ItoKiyotaka Toshimori
Feb 11, 2005·Archives of Histology and Cytology·Fumie Suzuki-ToyotaKiyotaka Toshimori
Jul 15, 2005·Molecular Reproduction and Development·Eugene RivkinAbraham L Kierszenbaum
Aug 2, 2005·Molecular and Cellular Biology·Hiromitsu TanakaYoshitake Nishimune
Dec 29, 2005·The Journal of Cell Biology·Melissa CrispDidier Hodzic
Dec 31, 2005·Biology of Reproduction·Zhibing ZhangJerome F Strauss
Aug 23, 2006·Molecular and Cellular Biology·Torsten HeldIbrahim M Adham
Jan 2, 2007·Experimental Cell Research·Murielle SaadeCatherine Nguyen
Mar 16, 2007·Biology of Reproduction·Fumie Suzuki-ToyotaKiyotaka Toshimori
Apr 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Huili ZhengWei Yan
Dec 19, 2008·Development·Jing ZhouGuo-Liang Xu
Jun 12, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Eugene RivkinLaura L Tres
Dec 8, 2009·Current Opinion in Cell Biology·Cosima T Baldari, Joel Rosenbaum
Jun 19, 2010·Molecular and Cellular Endocrinology·Jianqiang BaoWei Yan
Nov 26, 2010·Molecular Biology Reports·Xiao SunWan-Xi Yang
Feb 22, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Abraham L KierszenbaumRosa M Rios
May 18, 2011·The Journal of Cell Biology·Radhika GudiQingshen Gao
Feb 10, 2012·Spermatogenesis·Abraham L KierszenbaumLaura L Tres

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Citations

Nov 1, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Rupsha Fraser, Chih-Jen Lin
Sep 30, 2016·Molecular Biology of the Cell·Zhengang ZhangZhibing Zhang
Apr 25, 2018·International Journal of Molecular Sciences·Elizabeth KazarianMaria E Teves
Mar 8, 2018·Fish Physiology and Biochemistry·Yong-Qiang ZhaoJun-Quan Zhu
Oct 13, 2017·Biology of Reproduction·Mari S Lehti, Anu Sironen
Sep 7, 2018·Journal of Cell Science·Ferheen AbbasiMasahito Ikawa
Feb 1, 2019·Biological Reviews of the Cambridge Philosophical Society·Cátia D PereiraSandra Rebelo
Jan 3, 2019·Molecular Biology of the Cell·Céline AugièreBénédicte Durand
May 28, 2019·Andrology·Laura GirardetClémence Belleannée
Dec 23, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hidenobu OkudaMoira K O'Bryan
Mar 13, 2020·ELife·J Aaron CrapsterJames K Chen
Mar 12, 2020·The Journal of Biological Chemistry·Qian GaoQinghua Shi
May 28, 2020·International Journal of Molecular Sciences·Maria E TevesPaulene Sapao
Oct 24, 2018·The World Journal of Men's Health·Sezgin GunesAshok Agarwal
Apr 3, 2020·American Journal of Physiology. Cell Physiology·Wei QuZhibing Zhang
Mar 29, 2020·Animal Science Journal = Nihon Chikusan Gakkaihō·Wahono Esthi PrasetyaningtyasMokhamad Fahrudin
Apr 23, 2020·Human Reproduction Update·Christiane PleugerMoira K O'Bryan
Oct 22, 2019·Frontiers in Cell and Developmental Biology·Tomer Avidor-ReissPuneet Sindhwani
May 14, 2017·Histochemistry and Cell Biology·Przemysław ZakrzewskiMarta Lenartowska
Nov 18, 2018·Reproductive Biology and Endocrinology : RB&E·Kavindra Kumar KesariRalf Henkel
Oct 13, 2018·Journal of Human Genetics·Weiyu LiYunxia Cao
Sep 3, 2019·Frontiers in Cell and Developmental Biology·Constanza Tapia Contreras, Sigrid Hoyer-Fender
Nov 5, 2019·Frontiers in Cell and Developmental Biology·Gerhard van der HorstLiana Maree
Feb 13, 2020·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Khaled HabasDiana Anderson
Oct 14, 2020·Zygote : the Biology of Gametes and Early Embryos·Yi YuShenmin Yang
Jan 17, 2021·Journal of Assisted Reproduction and Genetics·Marziyeh Mazaheri MoghaddamEbrahim Sakhinia
Dec 31, 2020·Molecular Human Reproduction·F HanQ Y Sun
Nov 5, 2020·Scientific Reports·Yu OkitsuKeiichiro Yogo
Dec 18, 2020·Cells·Maria Giovanna RiparbelliGiuliano Callaini

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