Formation and inhibition of N-nitrosodiethanolamine in cosmetics under pH, temperature, and fluorescent, ultraviolet, and visual light

Journal of Toxicology and Environmental Health. Part a
Duck Soo LimByung-Mu Lee

Abstract

N-nitrosodiethanolamine (NDELA), a type of nitrosamine, is a possible human carcinogen that may form in cosmetic products. The aim of this study was to examine the formation and inhibition of NDELA through chemical reactions of secondary amines including mono-ethanolamine, di-ethanolamine (DEA), and tri-ethanolamine (TEA), and sodium nitrite (SN) under varying conditions such as pH, temperature, and fluorescent, ultraviolet (UV), and visual light (VIS) using liquid chromatography-mass spectroscopy. In a mixture of TEA and SN under acidic conditions pH 2, residual NDELA concentrations rose significantly under various storage conditions in the following order: 50°C > 40°C > UV (2 W/m2) > VIS (4000 lux) > fluorescent light > 25°C > 10°C. In a mixture of DEA and SN under the same acidic pH 2 conditions, NDELA formation was significantly elevated in the following order: UV (2 W/m2) > VIS (4000 lux) > 50°C > 40°C > fluorescent light > 25°C > 10°C. Inhibition of NDELA formation by d-mannitol, vitamin C (Vit C), or vitamin E (Vit E) was determined under varying conditions of pH, temperature, and fluorescent, UV, and VIS. At high concentrations of 100 or 1000 µg/ml, Vit E significantly decreased residual NDELA compared with control leve...Continue Reading

References

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Apr 1, 2016·Journal of Toxicology and Environmental Health. Part a·Ana Cláudia Ferreira SouzaMariana Machado-Neves
Aug 4, 2016·Journal of Toxicology and Environmental Health. Part a·Vidar BergJan L Lyche
Jun 10, 2017·Journal of Toxicology and Environmental Health. Part a·Sailendra Nath SarmaHing Man Chan
Jul 6, 2017·Journal of Toxicology and Environmental Health. Part a·Klara SlezakovaMaria do Carmo Pereira
Aug 31, 2017·Journal of Toxicology and Environmental Health. Part a·Hanne Friis BerntsenKarin Elisabeth Zimmer
Sep 8, 2017·Journal of Toxicology and Environmental Health. Part a·Ahmed A IsmailDiane S Rohlman

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Citations

Jan 22, 2019·Journal of Toxicology and Environmental Health. Part a·Byung-Mu LeeKyoungeun Kim
Feb 12, 2019·Journal of Toxicology and Environmental Health. Part a·Byung-Mu LeeKyoungeun Kim
Jan 1, 2020·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Keiko InamiMasataka Mochizuki
May 31, 2018·Journal of Toxicology and Environmental Health. Part a·Seul Min ChoiByung-Mu Lee

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