Formation and metabolism of 3',5'-diiodothyronine and 3,5-diiodothyronine by cultured monkey hepatocarcinoma cells

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
K Sorimachi, H J Cahnmann

Abstract

Cultured monkey hepatocarcinoma cells were incubated with [3',5'-125I] diiodo-L--thyronine and with [3,5-125I] diiodo-L-thyronine. In both instances monodeiodination as well as sulfoconjugation took place. [3.-125I] iodothyronine and [3',5'-125I] diiodothyronine were identified as metabolites of [3'-5'-125I]-L-thyroxine in the cells, but neither [3-125I]-iodothyronine nor [3,5-125I] diiodothyronine was detected after incubation of the cells with ]3,5-125I]-L-thyroxine. No products of diphenyl ether splitting were observed in the medium after incubation of the cells with either [3,5-125I] diiodo-L-thyronine or [3,5-125I]-L-thyroxine.

Citations

Aug 20, 2016·Organic & Biomolecular Chemistry·Santanu Mondal, Govindasamy Mugesh
Mar 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eric S Marsan, Craig A Bayse
Dec 19, 2019·Chemistry : a European Journal·Eric S Marsan, Craig A Bayse
May 27, 2016·Angewandte Chemie·Santanu MondalGovindasamy Mugesh

Related Concepts

Anthropoidea
Diiodothyronines
Malignant Neoplasm of Liver
Thyronine
Novothyral
Cytomel
Reverse Triiodothyronine

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