Mar 8, 2011

Formation and regulation of Yersinia biofilms

Protein & Cell
Dongsheng Zhou, Ruifu Yang

Abstract

Flea-borne transmission is a recent evolutionary adaptation that distinguishes the deadly Yersinia pestis from its progenitor Y. Pseudotuberculosis, a mild pathogen transmitted via the food-borne route. Y. Pestis synthesizes biofilms in the flea gut, which is important for fleaborne transmission. Yersinia biofilms are bacterial colonies surrounded by extracellular matrix primarily containing a homopolymer of N-acetyl-D-glucosamine that are synthesized by a set of specific enzymes. Yersinia biofilm production is tightly regulated at both transcriptional and post-transcriptional levels. All the known structural genes responsible for biofilm production are harbored in both Y. Pseudotuberculosis and Y. Pestis, but Y. Pestis has evolved changes in the regulation of biofilm development, thereby acquiring efficient arthropod-borne transmission.

  • References13
  • Citations39

Mentioned in this Paper

Enzymes, antithrombotic
Caenorhabditis elegans
Pathogenic Organism
Transcription, Genetic
Extracellular Matrix
Yersinia <bacteria>
Yersinia Infections
Yersinia
Enzymes for Treatment of Wounds and Ulcers
Yersinia Pseudotuberculosis Infections

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