Formation and removal of reactive oxygen species, lipid peroxides and free radicals, and their biological effects

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Tadashi Fujita

Abstract

It is well known that biomembranes and subcellular organelles are susceptible to lipid peroxidation. There is a steadily increasing body of evidence indicating that lipid peroxidation is involved in basic deteriorative mechanisms, e.g., membrane damage, enzyme damage, and nucleic acid mutagenicity. The formation of lipid peroxides can be induced by enzymatic or nonenzymatic peroxidation in the presence of oxygen. The mechanisms of formation and removal of reactive oxygen species, lipid peroxides, and free radicals in biological systems are briefly reviewed. In recent years, there has been renewed interest in the role played by lipid peroxidation in many disease states. Xanthine oxidase has been shown to generate reactive oxygen species, superoxide (O2-.), and hydrogen peroxide (H2O2) that are involved in the peroxidative damage to cells that occurs in ischemia-reperfusion injury. During ischemia, this enzyme is induced from xanthine dehydrogenase. We have shown that peroxynitrite (a reactive nitrogen species) has the potential to convert xanthine dehydrogenase to oxidase. The following biological effects of lipid peroxidation were found: a) the lipid peroxidation induced by ascorbic acid and Fe2+ affects the membrane transport ...Continue Reading

References

Nov 15, 1976·The Biochemical Journal·K NishikiB Chance
Dec 29, 1978·Biochemical and Biophysical Research Communications·M E HemlerW E Lands
Aug 28, 1979·Biochemical and Biophysical Research Communications·M I SiegelP Cuatrecasas
Jun 1, 1977·Japanese Journal of Pharmacology·M Yasuda, T Fujita
Apr 1, 1990·Trends in Biochemical Sciences·J M Gutteridge, B Halliwell
Dec 29, 1989·Biochemical and Biophysical Research Communications·D K DasP S Rao
Apr 25, 1989·Biochimica Et Biophysica Acta·M Wajner, R A Harkness
Jan 1, 1988·Free Radical Biology & Medicine·P BiemondJ F Koster
Jun 30, 1988·Biochemical and Biophysical Research Communications·H MinakamiA Sotomatsu
Feb 1, 1985·The Journal of Pharmacy and Pharmacology·Y FujimotoT Fujita
Mar 1, 1985·Archives of Biochemistry and Biophysics·J F TurrensA L Lehninger
Jan 1, 1987·Free Radical Biology & Medicine·R B Pendleton, W E Lands
May 21, 1986·Biochimica Et Biophysica Acta·C E DouglasP C Choy
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·A Sevanian, E Kim
Mar 1, 1985·Archives of Biochemistry and Biophysics·V C GavinoA L Tappel
Apr 30, 1971·Annals of the New York Academy of Sciences·W LandsW Smith
Jan 1, 1969·Biochimica Et Biophysica Acta·L Flohé, I Brand
Sep 1, 1982·The Biochemical Journal·H WakeyamaS Minakami
Oct 15, 1983·Archives of Biochemistry and Biophysics·M A Takahashi, K Asada
Apr 1, 1984·The Biochemical Journal·B Halliwell, J M Gutteridge
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J MacloufP Borgeat
Jun 1, 1983·Archives of Biochemistry and Biophysics·A SevanianS Montestruque
Jan 15, 1982·Biochimica Et Biophysica Acta·Y Fujimoto, T Fujita
Jul 1, 1982·British Journal of Pharmacology·Y Fujimoto, T Fujita
Jan 13, 1997·Biochemical and Biophysical Research Communications·S SakumaT Fujita
Nov 10, 1998·European Journal of Pharmacology·S TakaiM Miyazaki
Apr 15, 1972·FEBS Letters·G C.T. YeohI T. Oliver

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Citations

Mar 14, 2009·Journal of Oleo Science·Satomi FukaiMasato Nomura
Jun 2, 2005·Parasitology Research·L KolodziejczykE Skrzydlewska
Jan 22, 2008·Langenbeck's Archives of Surgery·Parimal Chowdhury, Azida Walker
Aug 22, 2009·Toxicology Mechanisms and Methods·Ewa SiemieniukElżbieta Skrzydlewska
Feb 3, 2016·Biological & Pharmaceutical Bulletin·Akihiro MichiharaMayuko Mido
Jan 29, 2008·Journal of Psychosomatic Research·Himani SharmaNeeta Singh
Dec 22, 2015·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Hanan H KamelGhada A Saad
Feb 14, 2008·Journal of Pharmacological Sciences·Masaki ArimaYasushi Koitabashi
Oct 25, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C PompéiaR Curi
Aug 5, 2017·Organic & Biomolecular Chemistry·Ayumi TsutsuiKatsunori Tanaka
Nov 26, 2008·Acta Cirúrgica Brasileira·Melih AkinciAbdullah Cetin
Nov 27, 2020·Environmental Science and Pollution Research International·Muhammet Yasin TekeliZeynep Soyer Sarıca

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