PMID: 8955562Jan 1, 1996Paper

Formation and retrieval of inhibitory avoidance memory: differential roles of glutamate receptors in the amygdala and medial prefrontal cortex

The Chinese Journal of Physiology
K C LiangS C Chang

Abstract

This study investigated the roles of NMDA and AMPA receptors in the amygdala and medial prefrontal cortex in formation and retrieval of affective memory. In a one-trial step-through inhibitory avoidance task, groups of rats with cannulae implanted into these two regions received infusion of 2.5 micrograms APV or 0.3 micrograms CNQX 5 min before training, shortly after training or 5 min prior to the 1-day or 21-day retention test. Results showed that pre- or posttraining intra-amygdala infusion of APV or CNQX induced a persistent retention deficit with the pretraining treatment causing a greater effect. Pre- or posttraining infusion of CNQX into the medial prefrontal cortex also induced a persistent retention deficit with the posttraining treatment causing a greater effect. Pre- or posttraining infusion of APV into the medial prefrontal cortex impaired 21-day retention but not 1-day retention. Pretraining infusion of lidocaine into either structure caused a retention deficit, which was not attenuated by activating the other structure with glutamate. Pretest intra-amygdala infusion of CNQX impaired memory expression in the 1-day test, while infusion of CNQX into the medial prefrontal cortex impaired memory expression in the 21-da...Continue Reading

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