Formation and transformation of calcium phosphate phases under biologically relevant conditions: Experiments and modelling

Acta Biomaterialia
Agnese CarinoAndrea Testino

Abstract

The experimental data on calcium phosphates formation were collected in dilute solution at constant pH (7.40) and temperature (37.0 °C) at different levels of ionic strength (IS). The evolution of the solid phase formation is described in detail using a thermodynamic-kinetic model. The thermodynamic model takes into account all relevant chemical species as well as Posner's clusters; the kinetic model, based on the discretized population balance approach, accounts for the solid formation from solution. The experimental data are consistent with an initial formation of dicalcium phosphate dihydrate (DCPD, brushite), which dominates the nucleation rate, and its rapid transformation into octacalcium phosphate (OCP) or hydroxyapatite (HA), which dominates the growth rate. Depending on the experimental conditions and, including the influence of the IS level, OCP may be further transformed into apatite. The classical nucleation theory is able to describe the experimental results very well and the solid phase growth is limited by the diffusion of Ca2+ ions. The precipitation pathway described by a complete thermodynamic-kinetic model is expected to contribute to the understating of the in vivo osteogenesis. The formation mechanism of ca...Continue Reading

Citations

Jan 27, 2019·Journal of Biomedical Materials Research. Part a·Yukari ShiwakuOsamu Suzuki
May 3, 2019·Nature Communications·Weitian ZhaoPaul Bowen
Jan 14, 2020·Journal of Colloid and Interface Science·E ColaçoJ Landoulsi
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Mari M SaitoYasuo Yamakoshi
Apr 24, 2021·Chemistry : a European Journal·Paula BorovikMatías Jobbágy
May 21, 2021·Advanced Drug Delivery Reviews·Noah Z LairdAliasger K Salem
Jul 13, 2021·Analytical Chemistry·Ludovica M EpastoDennis Kurzbach
May 8, 2020·Analytical Chemistry·Emmanuelle M M WeberDennis Kurzbach

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