PMID: 6859843Apr 1, 1983

Formation of (4R)- and (4S)-4-hydroxyochratoxin A and 10-hydroxyochratoxin A from Ochratoxin A by rabbit liver microsomes

Applied and Environmental Microbiology
F C StørmerA J Aasen


Three metabolites were formed from ochratoxin A in the presence of rabbit liver microsomal fractions and NADPH. They were isolated by extraction, thin-layer chromatography, and high-pressure liquid chromatography. Two of them were identified as (4R)- and (4S)-4-hydroxyochratoxin A. It is suggested on the basis of mass and nuclear magnetic resonance spectroscopy that the third metabolite is 10-hydroxyochratoxin A. The formation of the metabolites was inhibited by carbon monoxide and metyrapone and was stimulated when microsomes from phenobarbital-treated animals were used. The results suggest that cytochrome P-450 catalyzes the formation of these metabolites.


Sep 1, 1989·Mycopathologia·T LeaF C Størmer
Mar 1, 1995·Mycotoxin Research·M S CordeiroP J Moran
Jan 1, 1985·Critical Reviews in Toxicology·Y Ueno
Oct 1, 1994·Die Naturwissenschaften·M RuhlandP Wallnöfer
Oct 21, 2005·Human & Experimental Toxicology·L Alvarez-ErvitiA López de Cerain
Dec 30, 2006·Molecular Nutrition & Food Research·Annie Pfohl-Leszkowicz, Richard A Manderville
Jan 7, 2005·Molecular Nutrition & Food Research·Michael GekleGerald Schwerdt
Jul 8, 2016·Toxins·Frantisek MalirJakub Toman
Oct 28, 2015·Toxins·Alexandra H Heussner, Lewis E H Bingle
Feb 21, 2020·Toxins·Peng LiLigang Zhou

Related Concepts

Ochratoxin A
4-hydroxyochratoxin A, (3R-trans)-isomer
10-hydroxyochratoxin A
Carbon Monoxide
SU 4885
Microsomes, Liver
In Vivo NMR Spectroscopy

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.