PMID: 6859843Apr 1, 1983

Formation of (4R)- and (4S)-4-hydroxyochratoxin A and 10-hydroxyochratoxin A from Ochratoxin A by rabbit liver microsomes

Applied and Environmental Microbiology
F C StørmerA J Aasen

Abstract

Three metabolites were formed from ochratoxin A in the presence of rabbit liver microsomal fractions and NADPH. They were isolated by extraction, thin-layer chromatography, and high-pressure liquid chromatography. Two of them were identified as (4R)- and (4S)-4-hydroxyochratoxin A. It is suggested on the basis of mass and nuclear magnetic resonance spectroscopy that the third metabolite is 10-hydroxyochratoxin A. The formation of the metabolites was inhibited by carbon monoxide and metyrapone and was stimulated when microsomes from phenobarbital-treated animals were used. The results suggest that cytochrome P-450 catalyzes the formation of these metabolites.

Citations

Sep 1, 1989·Mycopathologia·T LeaF C Størmer
Mar 1, 1995·Mycotoxin Research·M S CordeiroP J Moran
Jan 1, 1985·Critical Reviews in Toxicology·Y Ueno
Oct 1, 1994·Die Naturwissenschaften·M RuhlandP Wallnöfer
Oct 21, 2005·Human & Experimental Toxicology·L Alvarez-ErvitiA López de Cerain
Dec 30, 2006·Molecular Nutrition & Food Research·Annie Pfohl-Leszkowicz, Richard A Manderville
Jan 7, 2005·Molecular Nutrition & Food Research·Michael GekleGerald Schwerdt
Jul 8, 2016·Toxins·Frantisek MalirJakub Toman
Oct 28, 2015·Toxins·Alexandra H Heussner, Lewis E H Bingle
Feb 21, 2020·Toxins·Peng LiLigang Zhou

Related Concepts

Ochratoxin A
4-hydroxyochratoxin A, (3R-trans)-isomer
10-hydroxyochratoxin A
Carbon Monoxide
Hydroxylation
SU 4885
Microsomes, Liver
NADP
In Vivo NMR Spectroscopy
Ochratoxins

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