Formation of a functional adrenergic input to intraocular cerebellar grafts: ingrowth of inhibitory sympathetic fibers.

Journal of Neurobiology
B J HofferF E Bloom

Abstract

The intraocular transplantation technique was used to study the ingrowth of peripheral sympathetic adrenergic nerves from the iris into transplants of fetal rat cerebellum, and the possible function of these nerves. The transplants, grown in oculo for one-half to eight months, were analyzed by fluorescence histochemistry and electrophysiological techniques. Peripheral sympathetic adrenergic fibers from the iris were able to grow into the cerebellar transplants and arborize in a pattern similar to that in situ, appearing in all three cortical layers and the noncortical areas of the transplants. The density of visible nerves without pretreatment and after preincubation in 10(-6) or 10(-5) M alpha-methylnorepinephrine was comparable to mature rat cerebellum. The spontaneous discharge of the Purkinje cells in oculo was inhibited by microiontophoresis of norepinephrine (NE) and amphetamine in sympathetically innervated, as well as sympathectomized transplants denervated by ganglionectomy. The NE response was blocked by the adrenergic beta-receptor blocker MJ-1999. GABA also inhibited the Purkinje cell activity while glutamate accelerated the discharge. Parenteral amphetamine inhibited Purkinje cell activity in sympathetically innerv...Continue Reading

References

Sep 1, 1973·Experimental Neurology·A L Leiman, F J Seil
Mar 1, 1974·Brain : a Journal of Neurology·G Neil-Dwyer, J Cruickshank
May 1, 1974·The Journal of Comparative Neurology·V M PickelF E Bloom
Nov 1, 1965·Acta Physiologica Scandinavica·T Malmfors
Jan 1, 1970·Histochemie. Histochemistry. Histochimie·L Olson, U Ungerstedt
Jan 1, 1971·Brain : a Journal of Neurology·M R Crompton
Sep 1, 1967·European Journal of Pharmacology·H CorrodiT Hökfelt
Feb 7, 1969·Science·M Jacobson
Jan 1, 1969·Histochemie. Histochemistry. Histochimie·L Olson
May 1, 1969·Brain Research·P Feltz, J S MacKenzie
Aug 1, 1965·Journal of Cellular Physiology·S NishiK Koketsu
Jun 1, 1966·Acta Physiologica Scandinavica·B Ehinger, B Falck
Jun 1, 1959·The American Journal of Physiology·F G CARPENTER, J C TANKERSLEY

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Citations

Apr 23, 2009·Neurotoxicity Research·Ribhi HazinDunia Saed
Jan 1, 1977·Progress in Neurobiology·D G Amaral, H M Sinnamon
Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·D TaylorB Hoffer
Mar 14, 2002·The Journal of Comparative Neurology·Beatriz Benítez-TemiñoAngel M Pastor
Jan 25, 2011·The Mount Sinai Journal of Medicine, New York·Dustin R WakemanJeffrey H Kordower
Aug 23, 2005·Brain Research. Brain Research Reviews·Beatriz Benítez-TemiñoAngel M Pastor
Nov 7, 2012·Cell Transplantation·Hueng-Chuen FanShinn-Zong Lin
Aug 26, 2011·Expert Review of Neurotherapeutics·Javier GanzDaniel Offen
Jan 1, 1984·Central Nervous System Trauma : Journal of the American Paralysis Association·A C GranholmA Seiger
Jul 10, 1982·The Journal of Comparative Neurology·D GoldowitzL Olson
Oct 23, 2018·ACS Chemical Neuroscience·Weizhao ChenMingtao Li

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