PMID: 6412010Sep 12, 1983Paper

Formation of benzophenone and alpha, alpha-diarylacetophenone metabolites of the antiestrogen nitromiphene (CI628) in the presence of rat cecal contents

Life Sciences
P C Ruenitz, J R Bagley

Abstract

Incubation of the nonsteroidal antiestrogen nitromiphene (CI628) with rat cecal content suspension under aerobic or anaerobic conditions resulted in extensive biotransformation, yielding three metabolites, as determined by thin-layer chromatography. These metabolites were not recovered from incubation mixtures containing previously frozen suspension, and recoveries were decreased (that of nitromiphene was increased) when incubations were carried out in the presence of 2mM EDTA. Spectral and chromatographic comparison of two of the purified metabolites resulted in their structural characterization, as p-[beta(N-pyrrolidinyl)ethoxy]p'-methoxybenzophenone, and a similarly substituted alpha, alpha-diphenyl-acetophenone. These metabolites are, in turn, due formally to ethylenic bond cleavage and nitro group reduction/hydrolysis of nitromiphene.

References

Jul 1, 1971·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M Mitchard

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