PMID: 8961564Dec 1, 1996Paper

Formation of cadaverine derivatives in Saccharomyces cerevisiae

FEMS Microbiology Letters
D R Walters, T Cowley

Abstract

The higher homologues of cadaverine, aminopropylcadaverine (APC) and N,N-bis(3-aminopropyl)cadaverine (3APC) were formed by a wild-type strain of Saccharomyces cerevisiae, and by two mutant strains, spe 3-1 and spe 4-1, exhibiting point mutations in the genes for spermidine synthase and spermine synthase, respectively. This, together with the incomplete inhibition of APC and 3APC formation in the presence of inhibitors of S-adenosylmethionine decarboxylase and spermidine synthase, suggests that the cadaverine derivatives are formed partly by the operation of a different route. However, the yeast strains were unable to utilise [14C]aspartate and lysine to form APC and 3APC. Since the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO) greatly reduced the formation of APC and 3APC, it is suggested that these compounds are formed preferentially in these yeast strains from cadaverine formed by ODC. APC and 3APC formation in the yeast strains was increased substantially following exposure to 37 degrees C for 2 h.

References

Jan 1, 1976·Biochemical Society Transactions·G H Tait
Jan 14, 1972·Biochemical and Biophysical Research Communications·H G Williams-Ashman, A Schenone
Oct 1, 1982·Journal of Bacteriology·T J PaulusR H Davis
Apr 29, 1980·Biochemical and Biophysical Research Communications·L Alhonen-Hongisto, J Jänne

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Citations

Oct 7, 1998·Microbiological Research·D Walters, T Cowley
Jul 15, 2015·Journal of Molecular Biology·Leonor Miller-FlemingMarkus Ralser
Aug 15, 1997·FEMS Microbiology Letters·D R WaltersA McPherson
Jul 4, 2021·Microbial Pathogenesis·Barbra ToplisAlfred Botha

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