Formation of calcium deficient HAp/collagen composites by hydrolysis of alpha-TCP.

Journal of Materials Science. Materials in Medicine
Ahmed H TounyPaul W Brown

Abstract

Bone-like composites containing calcium deficient hydroxyapatite (CDHAp) were formed by the hydrolysis of alpha-tricalcium phosphate (alpha-TCP) in the presence of type I collagen. CDHAp-collagen composites were synthesized using two techniques. In one technique alpha-TCP was mixed with non-milled (as-received) collagen prior to the addition of the aqueous solution. In the second, the collagen was milled with alpha-TCP in heptane at room temperature prior to its conversion to CDHAp. The effect of milling strongly facilitates the formation of CDHAp at physiological temperature. The proportion of milled collagen between 5 and 20 wt% present in the alpha-TCP/collagen composites has no significant effect on the rate of CDHAp formation. Variations in pH and in calcium and phosphate concentrations were determined as a function of collagen processing and variations specific to the presence of collagen were discerned. Compared to CDHAp or to composites containing non-milled collagen, diametrical and compressive strengths of CDHAp increased in the presence of milled collagen. Lack of collagen dispersion and incomplete formation of CDHAp during 48 h were the bases for reduced strengths of composites containing non-milled collagen.

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Citations

Oct 30, 2012·Journal of Materials Science. Materials in Medicine·Roman A Perez, Maria-Pau Ginebra
Feb 1, 2012·Computer Methods in Biomechanics and Biomedical Engineering·P J LiotierP Chabrand
Jun 7, 2013·Interface Focus·Kefeng WangXingdong Zhang

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