Formation of cystic ovarian follicles associated with elevated luteinizing hormone requires estrogen receptor-beta

Endocrinology
John F CouseKenneth S Korach

Abstract

Stringent regulation of LH secretion from the pituitary is vital to ovarian function in mammals. Two rodent models of LH hypersecretion are the transgenic LHbeta-C-terminal peptide (LHbetaCTP) and estrogen receptor-alpha (ERalpha)-null (alphaERKO) mice. Both exhibit ovarian phenotypes of chronic anovulation, cystic and hemorrhagic follicles, lack of corpora lutea, interstitial/stromal hyperplasia, and elevated plasma estradiol and testosterone. Because ERbeta is highly expressed in granulosa cells of the ovary, we hypothesized the intraovarian actions of ERbeta may be necessary for full manifestation of phenotypes associated with LH hyperstimulation. To address this question, we generated female mice that possess elevated LH, but lack ERbeta, by breeding the LHbetaCTP and ERbeta-null (betaERKO) mice. A comparison of LHbetaCTP, alphaERKO, and betaERKO(LHCTP) females has allowed us to elucidate the contribution of each ER form to the pathologies and endocrinopathies that occur during chronic LH stimulation of the ovary. alphaERKO ovaries respond to elevated LH by exhibiting an amplified steroidogenic pathway characteristic of the follicular stage of the ovarian cycle, whereas wild-type(LHCTP) and betaERKO(LHCTP) females exhibit a...Continue Reading

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Citations

Jun 7, 2005·Trends in Endocrinology and Metabolism : TEM·Philippa T K Saunders
Dec 13, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fuminori TaniguchiKenneth S Korach
May 5, 2005·Current Opinion in Obstetrics & Gynecology·Efstratios M KolibianakisPaul Devroey
Mar 3, 2006·The Journal of Clinical Investigation·Bonnie J Deroo, Kenneth S Korach
Apr 12, 2006·Reproductive Biology and Endocrinology : RB&E·David H AbbottDaniel A Dumesic
Aug 22, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Krairerk AthirakulDarryl C Zeldin
Feb 20, 2007·Annals of the New York Academy of Sciences·Karen D Carpenter, Kenneth S Korach
Aug 17, 2018·The Journal of Clinical Endocrinology and Metabolism·Mariarosaria Lang-MuritanoAnna Biason-Lauber
Mar 7, 2020·Endocrinology·V Praveen ChakravarthiM A Karim Rumi
Mar 15, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yukitomo AraoKenneth S Korach
Apr 21, 2020·Endocrine Reviews·Elisabet Stener-VictorinDavid H Abbott
Feb 17, 2021·Molecular and Cellular Endocrinology·V Praveen ChakravarthiM A Karim Rumi
Mar 7, 2021·Cells·Xue-Ling XuKun Yu
Mar 8, 2021·Molecular and Cellular Endocrinology·V Praveen ChakravarthiM A Karim Rumi
May 22, 2018·Best Practice & Research. Clinical Endocrinology & Metabolism·Sara Babcock GilbertT Rajendra Kumar
Dec 9, 2020·Molecular Aspects of Medicine·Camilla H K Hughes, Bruce D Murphy

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