PMID: 39419Jan 1, 1979

Formation of dityrosine by human salivary lactoperoxidase in vitro

Acta Odontologica Scandinavica
J Tenovuo, K Paunio

Abstract

The study dealt with the formation of dityrosine - a cross-link in some proteins including collagen - by human salivary lactoperoxidase. Dityrosine formation was found at pH range 6.6 to 9.3 with maximum reaction velocity at pH 8.5. However, thiocyanate ions at physiological salivary concentrations inhibited dityrosine formation by 70 to 80 per cent compared with the optimum rate. The inhibition seemed to result from the competition of SCN ions and L-tyrosine for the same binding site on enzyme surface. The possibility of dityrosine cross-linking in vivo in human oral fluid seems to be limited compared with e.g. human milk or macaque saliva where the concentration of SCN ions is low but the activity of lactoperoxidase is considerably high.

Citations

Jan 1, 1978·Archives of Oral Biology·J Tenovuo
Jan 1, 1976·Connective Tissue Research·P Waykole, E Heidemann
Jul 1, 1977·Scandinavian Journal of Dental Research·J Tenovuo, S S Sarimo
May 1, 1978·The Journal of Nutrition·K K MäkinenG Fitzgerald
Jul 1, 1976·Journal of Dental Research·K K MäkinenA Scheinin
Jan 1, 1976·Acta Odontologica Scandinavica·K K Mäkinen, J Tenovuo
Jun 1, 1977·Biopolymers·M A Stahmann, A K Spencer
Jun 1, 1977·Biopolymers·M A Stahmann, A K Spencer
Jul 1, 1976·Journal of Dental Research·J Tenovuo, K K Mäkinen
Sep 19, 1972·Biochimica Et Biophysica Acta·G S BayseM Morrison
Jan 1, 1970·Archives of Biochemistry and Biophysics·C S Pande, R H McMenamy
Feb 26, 1968·Biochemical and Biophysical Research Communications·F LaBellaG Queen
Oct 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·H SobelR S Pogrund
Mar 21, 1967·Biochemical and Biophysical Research Communications·F LaBellaD Thornhill
Feb 5, 1963·Biochimica Et Biophysica Acta·S O ANDERSEN
Feb 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·S J KLEBANOFF, R G LUEBKE

Related Concepts

Ovoperoxidase
Salivary Peptides
LPO
Saliva - SpecimenType
Thiocyanate Measurement
Ligand Binding Domain
Lactoperoxidase
Milk, Human
Metabolic Inhibition
Saliva

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