Formation of dominant mode by evolution in biological systems

Physical Review. E
Chikara Furusawa, Kunihiko Kaneko

Abstract

A reduction in high-dimensional phenotypic states to a few degrees of freedom is essential to understand biological systems. Here, we show evolutionary robustness causes such reduction which restricts possible phenotypic changes in response to a variety of environmental conditions. First, global protein expression changes in Escherichia coli after various environmental perturbations were shown to be proportional across components, across different types of environmental conditions. To examine if such dimension reduction is a result of evolution, we analyzed a cell model-with a huge number of components, that reproduces itself via a catalytic reaction network-and confirmed that common proportionality in the concentrations of all components is shaped through evolutionary processes. We found that the changes in concentration across all components in response to environmental and evolutionary changes are constrained to the changes along a one-dimensional major axis, within a huge-dimensional state space. On the basis of these observations, we propose a theory in which such constraints in phenotypic changes are achieved both by evolutionary robustness and plasticity and formulate this proposition in terms of dynamical systems. Accor...Continue Reading

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Citations

May 25, 2018·Annual Review of Biophysics·Kunihiko Kaneko, Chikara Furusawa
Jun 20, 2019·Journal of the Royal Society, Interface·Holger Flechsig, Alexander S Mikhailov
May 19, 2020·Molecular Biology and Evolution·Kabir Husain, Arvind Murugan
Apr 14, 2020·PLoS Computational Biology·Miguel Brun-UsanRichard A Watson
Jun 24, 2020·Biophysics Reviews·Chikara Furusawa, Naoki Irie
Feb 19, 2021·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Takahiro Kohsokabe, Kunihiko Kaneko

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