Formation of droplets and bubbles in a microfluidic T-junction-scaling and mechanism of break-up

Lab on a Chip
Piotr GarsteckiGeorge M Whitesides

Abstract

This article describes the process of formation of droplets and bubbles in microfluidic T-junction geometries. At low capillary numbers break-up is not dominated by shear stresses: experimental results support the assertion that the dominant contribution to the dynamics of break-up arises from the pressure drop across the emerging droplet or bubble. This pressure drop results from the high resistance to flow of the continuous (carrier) fluid in the thin films that separate the droplet from the walls of the microchannel when the droplet fills almost the entire cross-section of the channel. A simple scaling relation, based on this assertion, predicts the size of droplets and bubbles produced in the T-junctions over a range of rates of flow of the two immiscible phases, the viscosity of the continuous phase, the interfacial tension, and the geometrical dimensions of the device.

References

Jan 14, 2000·Electrophoresis·J C McDonaldG M Whitesides
May 1, 2001·Physical Review Letters·T ThorsenS R Quake
Sep 19, 2002·Proceedings of the National Academy of Sciences of the United States of America·Stephan K W DertingerGeorge M Whitesides
Oct 2, 2003·Nature Biotechnology·Jong Wook Hong, Stephen R Quake
Nov 20, 2003·Journal of the American Chemical Society·Helen Song, Rustem F Ismagilov
Jan 22, 2004·Angewandte Chemie·Samuel K SiaGeorge M Whitesides
Mar 3, 2004·BioTechniques·Todd A Thorsen
Jul 23, 2004·Lab on a Chip·Axel GüntherKlavs F Jensen
Nov 3, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Shingo OkushimaToshiro Higuchi
Mar 9, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Dhananjay DendukuriPatrick S Doyle
Apr 20, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Won Je JeongSang Hoon Lee
May 18, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Minseok SeoEugenia Kumacheva
May 19, 2005·Journal of the American Chemical Society·Jing SuMilan Mrksich
May 21, 2005·Physical Review Letters·Piotr GarsteckiGeorge M Whitesides
Dec 1, 1998·Analytical Chemistry·D C DuffyG M Whitesides

❮ Previous
Next ❯

Citations

Nov 5, 2010·Analytical and Bioanalytical Chemistry·Dario Lombardi, Petra S Dittrich
Apr 28, 2011·Analytical and Bioanalytical Chemistry·Masahiro Takinoue, Shoji Takeuchi
May 30, 2009·Biomedical Microdevices·Fang Wang, Mark A Burns
Jun 5, 2007·Analytical Chemistry·Allyson E SgroDaniel T Chiu
Jun 17, 2010·Analytical Chemistry·Dawn E CohenDaniel T Chiu
Jun 13, 2008·Analytical Chemistry·Meng WangRobert T Kennedy
Jun 25, 2009·Analytical Chemistry·Margaret Macris KissJohn H Leamon
Oct 26, 2011·Biomacromolecules·Kelly M SchultzEric M Furst
Apr 6, 2013·Nature Protocols·Linas MazutisJohn A Heyman
Apr 28, 2009·Molecular BioSystems·Hagan BayleyMark Wallace
Oct 15, 2009·Chemical Communications : Chem Comm·X Z NiuA J deMello
May 7, 2010·Lab on a Chip·Fang Wang, Mark A Burns
Nov 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Delai ChenRustem F Ismagilov
May 29, 2009·Journal of the Royal Society, Interface·Shelly GulatiAndrew J deMello
Mar 20, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Matthew T Sullivan, Howard A Stone
May 18, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Luz Amaya-Bower, Taehun Lee
Jun 28, 2012·Journal of Biomedical Optics·Christine M O'BrienJohn A Viator
May 27, 2011·Journal of Biological Engineering·Mandy Ly SinPak Kin Wong
May 10, 2013·PloS One·Dennis J EastburnAdam R Abate
Jul 7, 2011·International Journal of Molecular Sciences·Hao GuFrieder Mugele
Jan 9, 2014·Analytical Chemistry·Thomas R GibbTim Albrecht
Aug 21, 2009·Biomicrofluidics·Kuo-Yuan ChungKeng-Hui Lin
May 8, 2013·Therapeutic Delivery·Sally A PeymanStephen D Evans
Jan 8, 2014·Lab on a Chip·Riëlle de RuiterFrieder Mugele
Nov 28, 2012·Biosensors & Bioelectronics·Jie ChouJohn T McDevitt
Jun 2, 2012·Biomicrofluidics·Sharon M Vuong, Shelley L Anna
Jun 2, 2012·Biomicrofluidics·Ya-Wen ChangZhengdong Cheng
Jun 2, 2012·Biomicrofluidics·Robert LinAbraham P Lee
Jan 10, 2014·Biomicrofluidics·Volkert van SteijnPiotr Garstecki
Jan 26, 2011·Biomicrofluidics·Swastika S Bithi, Siva A Vanapalli
Dec 18, 2013·Biomedical Microdevices·Xuan MuGuoan Luo
Aug 21, 2013·Advanced Drug Delivery Reviews·A M Gañán-CalvoM Flores-Mosquera
Nov 8, 2014·Biomicrofluidics·Minsoung RheeAnup K Singh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Gordon F ChristopherS L Anna
Lab on a Chip
Takasi NisisakoToshiro Higuchi
Langmuir : the ACS Journal of Surfaces and Colloids
S van der GraafRemko Boom
© 2021 Meta ULC. All rights reserved