Formation of gallic acid layer on γ-AlOOH nanoparticles surface and their antioxidant and membrane-protective activity

Journal of Inorganic Biochemistry
I S MartakovP A Sitnikov

Abstract

In the reported study we prepared gallic acid modified γ-AlOOH nanoparticles. We proposed mechanism of phenolic compounds binding on the alumina, suggesting covalent and electrostatic interactions. Most of the properties of alumina nanoparticles (NPs) are unchanged, but there is partial reduction of surface charge. Prepared samples are colloidally stable hydrosols. It allowed us to perform biological studies on cellular and non-cellular models, which showed nontoxicity of both pure and hybrid γ-AlOOH nanoparticles. Furthermore, pure alumina NPs exhibit antioxidant properties, which are enhanced after gallic acid immobilization on their surface. Also, hybrid alumina-gallic acid NPs showed membrane-protective activity.

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Citations

Jun 17, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Mohamed S SelimXiang Chen

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