PMID: 6114489May 1, 1981

Formation of gamma-glutamycyst(e)ine in vivo is catalyzed by gamma-glutamyl transpeptidase

Proceedings of the National Academy of Sciences of the United States of America
O W GriffithA Meister

Abstract

These studies indicate that gamma-glutamylcyst(e)ine, found in the urine of a patient with gamma-glutamyl transpeptidase deficiency and also in the urine of experimental animals injected with glutathione or with inhibitors of gamma-glutamyl transpeptidase, is formed by the action of gamma-glutamyltranspeptidase. The evidence demonstrates that transpeptidation between glutathione and cystine occurs in vivo and also that this reaction constitutes a significant physiological function of the enzyme. The appearance of large amounts of gamma-glutamylcyst(e)ine in the urine seems to reflect an inhibitory effect of glutathione on the transport of gamma-glutamylcyst(e)ine into cells. The findings also indicate that conversion of glutathione to gamma-glutamylcysteine by hydrolytic cleavage of the COOH-terminal glycine moiety of glutathione (or analogous cleavage of glutathione disulfide) is not a quantitatively significant pathway. The results reported here show that gamma-glutamyl transpeptidase activity is not completely absent in a patient found to have a deficiency of this enzyme and that the activity of the enzyme is not abolished in experimental animals treated with potent gamma-glutamyl transpeptidase inhibitors.

References

Jan 1, 1976·Annual Review of Biochemistry·A Meister, S S Tate
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·O W Griffith, A Meister
May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·O W GriffithA Meister
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·O W Griffith, A Meister
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·O W GriffithA Meister
Jun 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·G A Thompson, A Meister
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·O W Griffith, A Meister

Citations

Sep 25, 1981·Molecular and Cellular Biochemistry·S S Tate, A Meister
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M E AndersonA Meister
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M E Anderson, A Meister
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M E Anderson, A Meister
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S R Abul-EzzS V Shah
Apr 17, 2012·Seminars in Cell & Developmental Biology·Hongqiao Zhang, Henry Jay Forman
Jun 1, 1985·Archives of Biochemistry and Biophysics·M E AndersonA Meister
Dec 15, 1982·Biochemical and Biophysical Research Communications·K Bernström, S Hammarström
Nov 18, 2000·The Journal of Biological Chemistry·D R KarpP E Lipsky
Apr 9, 2009·Chemistry & Biodiversity·Manjeet DeshmukhPatrick Sinko

Related Concepts

Gamma-glutamylcysteine
4-vinylpyridine sulfate (1: 1)
2-vinylpyridine
Gamma-glutamylcystine
Cysteine Hydrochloride
Dipeptides
Gamma-glutamyl transferase
Glutamic Acids
Reduced Glutathione
Kidney

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