Formation of intracerebral cavernous malformations after radiation treatment for central nervous system neoplasia in children

Journal of Neurosurgery
J J LarsonJ M Tew

Abstract

Radiation is a common treatment modality for pediatric brain tumors. The authors present a retrospective review of six children who developed cerebral cavernous malformations after they underwent radiation treatment for central nervous system (CNS) neoplasia and propose two possible models to explain the formation of cavernous malformations. Three boys, aged 13, 9, and 17 years, suffered intracerebral hemorrhages from cerebral cavernous malformations 87, 94, and 120 months, respectively, after they received whole-brain radiation therapy (WBRT) for acute lymphocytic leukemia. A 10-year-old girl and a 19-year-old man developed temporal lobe cavernous malformations 46 and 48 months, respectively, after they received radiation therapy for posterior fossa astrocytomas. A 12-year-old girl developed a temporal lobe cavernous malformation 45 months after WBRT was administered for a medulloblastoma. In all of these cases the cavernous malformation appeared in the irradiated field, was not known to be present prior to radiation therapy, and developed after a latency period following treatment. The incidence of cavernous malformations in these patients suggests that children who undergo radiation therapy of the brain may have an increased...Continue Reading

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Citations

Jan 22, 2005·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Raphaël DuhemPatrick Dhellemmes
Apr 12, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Daniel L KeeneEnrique Ventureyra
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Methods Mentioned

BETA
biopsy
surgical resection

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