PMID: 7542478Jul 6, 1995Paper

Formation of membrane channels by chrysospermins, new peptaibol antibiotics

Biochimica Et Biophysica Acta
P GrigorievU Gräfe

Abstract

The four homologous chrysospermins (Ia-d) are new 19 amino acid peptaibols which form cation selective ion channels in artificial lipid bilayer membranes. Conductance of channels formed by chrysospermins B (Ib) and D (Id) was twice as high (640 pS in 100 mM KCl) as found with chrysospermins A (Ia) and C (Ic). Single channel current traces were recorded for each of the four peptides even at very low (even zero) membrane voltages suggesting that non-gated channels are formed.

References

Jan 1, 1974·The Journal of Membrane Biology·G Boheim

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Citations

Nov 28, 2009·Toxicon : Official Journal of the International Society on Toxinology·Nicolas RuizYves François Pouchus
Jul 20, 2017·Journal of Natural Products·Joshua A Homer, Jonathan Sperry
Oct 3, 1999·Journal of Peptide Science : an Official Publication of the European Peptide Society·S J LeeI D Yoo
Apr 1, 1999·Journal of Peptide Science : an Official Publication of the European Peptide Society·R GessmannM Kokkinidis
Aug 26, 1998·The Journal of Peptide Research : Official Journal of the American Peptide Society·R AndersL R Brown
Feb 6, 2009·Chemical Research in Toxicology·Alexey G KruglovMirja S Salkinoja-Salonen

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