Formation of micronucleated erythrocytes in mouse bone-marrow under conditions of hypothermia is not associated with stimulation of erythropoiesis

Mutation Research
Antonio GuzmánRicard Marcos

Abstract

Conditions of marked and long-lasting hypothermia have been shown to increase the formation of micronucleated polychromatic erythrocyte (MNPCE) in mouse bone-marrow. Stimulation of erythropoiesis as a consequence of anoxic conditions associated with decreased body temperature has been suggested as a possible mechanism for hypothermia-induced micronucleus formation. We examined whether chemically induced hypothermic conditions that produced increased MNPCE formation were associated with stimulation of erythropoiesis by measuring erythropoietin (EPO) concentrations in blood. Marked and long-lasting hypothermia was induced in male mice by oral administration of the antipsychotic compounds E-5842 (200 mg/kg) or chlorpromazine (100 mg/kg). Maximum decreases from the basal temperature, achieved 8 h after treatment, were 14.8 and 12.8 degrees C, respectively. A statistically significant increase in bone-marrow MNPCE frequency was observed 48 h after administration of E-5842 (p<0.01) or chlorpromazine (p<0.05). Mice made anaemic by retro-orbital bleeding (0.5 ml), which acted as positive control for stimulation of erythropoiesis, showed no relevant variation in mean rectal temperature and a slight non-statistically significant increase...Continue Reading

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Citations

Sep 3, 2011·Nature Reviews. Molecular Cell Biology·Leo D Wang, Amy J Wagers
Feb 15, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Anette ThielPaul Beilstein
Sep 15, 2012·Mutation Research·Henning HintzscheHelga Stopper
Nov 9, 2016·Frontiers in Endocrinology·Ana María PinoClifford J Rosen
Dec 10, 2016·Psychopharmacology·Yury S TarahovskyNadezhda M Zakharova

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