Formation of molecular radical cations of enkephalin derivatives via collision-induced dissociation of electrospray-generated copper (II) complex ions of amines and peptides

Journal of the American Society for Mass Spectrometry
I K ChuT C Lau

Abstract

Fragmentation of some electrospray-generated complex ions, [63CuII(amine)M].2+, where M is an enkephalin derivative, produces the radical cation of the peptide, M.+. This ion has only been observed when M contains a tyrosyl or tryptophanyl residue plus a basic residue, typically arginyl or lysyl. A typical viable amine is diethylenetriamine. Collision-induced dissociation (CID) of the M.+ ion yields a prominent [M - 106].+ product ion for tyrosine-containing peptides, and a prominent [M - 129].+ ion for a tryptophan-containing peptide. These fragment ions are formed as a result of elimination of the tyrosyl and tryptophanyl side chains. Dissociation of these ions, in turn, produces second generation product ions, many of which are typically absent in the fragmentation of protonated peptide ions. Structures for some of these unusual ions are proposed.

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Citations

May 28, 2003·Mass Spectrometry Reviews·Roman A Zubarev
Dec 31, 2011·Journal of the American Society for Mass Spectrometry·Benjamin MooreRyan R Julian
Aug 23, 2012·Journal of the American Society for Mass Spectrometry·Lei Tan, Yu Xia
Feb 27, 2013·Journal of the American Society for Mass Spectrometry·Justin Kai-Chi LauAlan C Hopkinson
Oct 4, 2005·Journal of the American Society for Mass Spectrometry·Ivan K Chu, Corey N W Lam
Jul 1, 2006·Journal of the American Society for Mass Spectrometry·Corey N W Lam, Ivan K Chu
Nov 8, 2008·Journal of the American Society for Mass Spectrometry·Rafał FrańskiGrzegorz Schroeder
Mar 4, 2009·Journal of the American Society for Mass Spectrometry·Chi-Kit SiuK W Michael Siu
May 30, 2009·Journal of the American Society for Mass Spectrometry·Liangyi Zhang, James P Reilly
Feb 9, 2010·Journal of the American Society for Mass Spectrometry·Julia LaskinIvan K Chu
Sep 28, 2010·Journal of the American Society for Mass Spectrometry·John R Lloyd, Sonja Hess
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