Formation of monodisperse calcium alginate microbeads by rupture of water-in-oil-in-water droplets with an ultra-thin oil phase layer

Lab on a Chip
Daisuke SaekiSosaku Ichikawa

Abstract

This paper reports a novel formation method of monodisperse calcium alginate microbeads from water-in-oil-in-water (W/O/W) droplets with an ultra-thin oil phase layer. W/O/W droplets containing sodium alginate in an internal aqueous phase were formed as a template of calcium alginate microbeads using a microfluidic device. The ultra-thin oil phase layer of the W/O/W droplets was ruptured by an osmotic pressure difference between the internal and external aqueous phase. Immediately after the rupture, polyanionic alginate in the internal aqueous phase was cross-linked with calcium ion diffused from the external aqueous phase, and monodisperse and spherical calcium alginate microbeads were formed.

References

Mar 20, 2001·Journal of Colloid and Interface Science·Lixiong Wen, Kyriakos D. Papadopoulos
Dec 18, 2004·Biomaterials·Shinji SugiuraMitsutoshi Nakajima
Sep 14, 2006·Journal of the American Chemical Society·Hong ZhangEugenia Kumacheva
Oct 18, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Kan LiuXing-Zhong Zhao
Nov 16, 2006·Biomedical Microdevices·Shinji SugiuraMitsutoshi Nakajima

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Citations

Aug 1, 2013·Advanced Drug Delivery Reviews·Goran T VladisavljevićIsao Kobayashi
Jul 23, 2015·Macromolecular Bioscience·Linas MazutisDavid A Weitz
Nov 11, 2014·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Ankur S ChaurasiaShahriar Sajjadi
Dec 14, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Hirotada HiramaToru Torii

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