Formation of nano-bio-complex as nanomaterials dispersed in a biological solution for understanding nanobiological interactions.

Scientific Reports
Mingsheng XuNobutaka Hanagata

Abstract

Information on how cells interface with nanomaterials in biological environments has important implications for the practice of nanomedicine and safety consideration of nanomaterials. However, our current understanding of nanobiological interactions is still very limited. Here, we report the direct observation of nanomaterial bio-complex formation (other than protein corona) from nanomaterials dispersed in biologically relevant solutions. We observed highly selective binding of the components of cell culture medium and phosphate buffered saline to ZnO and CuO nanoparticles, independent of protein molecules. Our discoveries may provide new insights into the understanding of how cells interact with nanomaterials.

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Citations

Oct 1, 2013·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·I-Lun Hsiao, Yuh-Jeen Huang
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Methods Mentioned

BETA
transmission electron microscopy
X-ray
scanning
electrophoresis

Software Mentioned

FBS

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