Formation of new myotubes occurs exclusively at the multiple innervation zones of an embryonic large muscle

Developmental Dynamics : an Official Publication of the American Association of Anatomists
M J Duxson, P Sheard

Abstract

This work examines the general principle of whether production of embryonic muscle fibres is invariably linked to sites of innervation, as we have previously reported in small rodent muscles (Duxson et al. [1989] Development 107:743-750). The experimental strategy has been to make a detailed electron microscopic analysis of the formation of new myotubes in a large muscle having multiple, discrete innervation zones. The particular model system is the guinea pig sternomastoid muscle, a strap-like, parallel-fibred muscle with four distinct endplate bands, both in the embryo and the adult. Primary myotubes in the developing muscle extended from tendon to tendon of the muscle and were innervated at each of the multiple endplate zones. Each point of innervation of the primary myotubes was a focus around which many new secondary myotubes formed, and each secondary myotube was approximately centred on one of the innervation sites of its supporting primary myotube. This confirms our previous report, in rat IVth lumbrical muscle, of an invariable association between sites of formation of new secondary myotubes and sites of innervation. We suggest that, in vivo, nerve terminals either directly induce the initial myoblast fusions which giv...Continue Reading

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Citations

Feb 20, 1997·Brain Research. Developmental Brain Research·P W Sheard, M J Duxson
Feb 28, 2002·Current Opinion in Neurobiology·Silvia ArberA John Harris
Apr 3, 2010·Journal of Applied Physiology·Zoia C LatevaM Elise Johanson
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Feb 13, 2002·The Journal of Cell Biology·Angelika C Paul, Nadia Rosenthal
Apr 27, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Daniel Eberhard, Harald Jockusch

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