Formation of organic nanoparticles from volatile microemulsions

Journal of Colloid and Interface Science
Katrin Margulis-GoshenShlomo Magdassi

Abstract

A method for preparation of nanoparticles of poorly water-soluble organic materials is presented. By this method, an oil-in-water microemulsion containing a volatile solvent with dissolved model material, propylparaben, undergoes solvent evaporation and conversion into nanoparticles by spray drying. The resulting powder can be easily dispersed in water to give a clear, stable dispersion of nanoparticles with a high loading of propylparaben. By filtration of this dispersion it was found that more than 95wt.% of the dispersed propylparaben is in particles of less than 450nm. X-ray diffraction revealed that propylparaben is present as nanocrystals of 40-70nm. After dispersion of the powder in water, formation of large crystals rapidly occurs. Addition of polyvinylpyrrolidone (PVP) prevented crystal growth during dispersion of the powder in water. The inhibition of propylparaben crystal growth by PVP was studied by molecular dynamic simulations that addressed the binding of PVP to the propylparaben crystal. A comparison was made between PVP and polyvinylalcohol, which did not display crystal inhibition properties.

References

May 1, 1970·Journal of Pharmaceutical Sciences·A P SimonelliW I Higuchi
Feb 15, 1997·Journal of Colloid and Interface Science·L QiJ Shen
Aug 11, 1999·Pharmaceutical Science & Technology Today·B H Böhm, R H Müller
Jun 6, 2000·Advanced Drug Delivery Reviews·J W McGinity, P B O'Donnell
Dec 6, 2000·Advanced Drug Delivery Reviews·M J Lawrence, G D Rees
Feb 13, 2001·International Journal of Pharmaceutics·S L RaghavanJ Hadgraft
Mar 15, 2001·Drug Development and Industrial Pharmacy·R G AlanyT Rades
Aug 3, 2001·Journal of Colloid and Interface Science·T. BeitzS. E. Friberg
Oct 31, 2002·Angewandte Chemie·Dieter Horn, Jens Rieger
Mar 8, 2003·International Journal of Pharmaceutics·Michele TrottaSilvia Morel
Feb 7, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·C DestréeJ B Nagy
Apr 25, 2007·Journal of Pharmaceutical Sciences·Hajime IshidaLian Yu
Jun 20, 2008·Journal of Colloid and Interface Science·Lennart LindforsUlf Olsson
Mar 10, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Katy Margulis-Goshen, Shlomo Magdassi

❮ Previous
Next ❯

Citations

Sep 14, 2012·Environmental Science and Pollution Research International·R S Suresh KumarN Chandrasekaran
Mar 16, 2013·Physical Chemistry Chemical Physics : PCCP·Katrin Margulis-GoshenLuciano Galantini
Jan 24, 2012·Nanoscale Research Letters·Alberto Gutiérrez-BecerraJosé I Escalante
Mar 30, 2010·Expert Opinion on Drug Delivery·Leena PeltonenJouni Hirvonen
Jun 2, 2011·Journal of Pharmaceutical Sciences·Katrin Margulis-GoshenShlomo Magdassi
Jun 14, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Fitsum F SahleReinhard H H Neubert
Aug 8, 2014·Journal of Pharmaceutical Sciences·William Wei Lim ChinRajeev Gokhale
Sep 14, 2010·Ecotoxicology and Environmental Safety·C H AnjaliN Chandrasekaran
Apr 21, 2010·International Journal of Pharmaceutics·Katrin Margulis-GoshenShlomo Magdassi
Aug 29, 2013·Journal of Veterinary Pharmacology and Therapeutics·J M BermudezS Palma
Jul 31, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Fitsum F SahleReinhard H H Neubert
Mar 29, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Michelle P DvoresShlomo Magdassi
Sep 4, 2018·Expert Opinion on Therapeutic Patents·Marluce Pereira Damasceno LimaFernanda Regina de Castro Almeida

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Nanomedicine : Nanotechnology, Biology, and Medicine
Katy Margulis-Goshen, Shlomo Magdassi
Journal of Controlled Release : Official Journal of the Controlled Release Society
Amnon C SintovShafir Botner
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Rania M HathoutRichard H Guy
Nature Reviews. Drug Discovery
Barrett E Rabinow
International Journal of Pharmaceutics
Katrin Margulis-GoshenShlomo Magdassi
© 2022 Meta ULC. All rights reserved