Formation of palmitic acid/Ca2+ complexes in the mitochondrial membrane: a possible role in the cyclosporin-insensitive permeability transition

Journal of Bioenergetics and Biomembranes
Galina D MironovaMichel Ovize

Abstract

A possible role of palmitic acid/Ca2+ (PA/Ca2+) complexes in the cyclosporin-insensitive permeability transition in mitochondria has been studied. It has been shown that in the presence of Ca2+, PA induces a swelling of mitochondria, which is not inhibited by cyclosporin A. The swelling is accompanied by a drop in membrane potential, which cannot be explained only by a work of the Ca2+ uniporter. With time, the potential is restored. Evidence has been obtained indicating that the specific content of mitochondrial lipids would favor the PA/Ca2+ -induced permeabilization of the membrane. In experiments with liposomes, the PA/Ca2+ -induced membrane permeabilization was larger for liposomes formed from the mitochondrial lipids, as compared to the azolectin liposomes. Additionally, it has been found that in mitochondria of the TNF (tumor necrosis factor)-sensitive cells (WEHI-164 line), the content of PA is larger than in mitochondria of the TNF-insensitive cells (C6 line), with this difference being mainly provided by PA incorporated in phosphatidylethanolamine and especially, cardiolipin. The PA/Ca2+ -dependent mechanism of permeability transition in mitochondria might be related to some pathologies, e.g. myocardial ischemia. The ...Continue Reading

Citations

Jul 19, 2006·Journal of Bioenergetics and Biomembranes·Konstantin BelosludtsevGalina D Mironova
May 29, 2007·Journal of Bioenergetics and Biomembranes·Galina D MironovaNils-Erik L Saris
Sep 15, 2014·European Biophysics Journal : EBJ·Mikhail V DubininKonstantin N Belosludtsev
Feb 19, 2015·Journal of Bioenergetics and Biomembranes·Aleksander A VedernikovVictor N Samartsev
Dec 29, 2004·Biochimica Et Biophysica Acta·Mario ZorattiUmberto De Marchi
Mar 7, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·Maria Fernanda Cury-BoaventuraRui Curi
Oct 3, 2006·Journal of Cellular Physiology·Sandro M HirabaraRui Curi
Nov 22, 2015·Bioscience Reports·Moacir Wajner, Alexandre Umpierrez Amaral
Mar 17, 2009·Toxicon : Official Journal of the International Society on Toxinology·Aline Buda dos SantosFábio Erminio Mingatto

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