PMID: 3754157Apr 15, 1986Paper

Formation of prostacyclin and thromboxane in man as measured by the main urinary metabolites

Biochimica Et Biophysica Acta
S FischerP C Weber

Abstract

Excretion of 2,3-dinor-6-ketoprostaglandin F1 alpha and 2,3-dinorthromboxane B2, the main urinary metabolites of prostacyclin and thromboxane, was evaluated by gas chromatography-mass spectroscopy and radioimmunoassay, respectively, at various conditions in man. In healthy young males excretion of 2,3-dinor-6-ketoprostaglandin F1 alpha was of little variability, whereas urinary 2,3-dinorthromboxane B2 showed marked interindividual but moderate intraindividual variations. The ratio of urinary 2,3-dinorthromboxane B2 to thromboxane B2 in young males was about 15. Excretion of 2,3-dinor-6-ketoprostaglandin F1 alpha in women of reproductive age was higher (155 +/- 23 ng/g creatinine, P less than 0.005) than in postmenopausal women (97 +/- 24 ng/g creatinine) and in men (78 +/- 7.6 ng/g creatinine) and increased significantly during pregnancy (1st trimester 230 +/- 50 ng/g creatinine; 3rd trimester 522 +/- 53 ng/g creatinine). Urinary 2,3-dinorthromboxane B2 showed no gender differences and no directed change was observed during pregnancy. In neonates urinary 2,3-dinorthromboxane B2 (6.328 +/- 1.210 ng/g creatinine) was high in their 3rd day of life and decreased rapidly thereafter. This pattern paralleled the behavior of 6-ketopros...Continue Reading

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Citations

Feb 1, 1995·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·M Kotamäki
Jan 1, 1990·Chemico-biological Interactions·M L SelleyN G Ardlie
May 1, 1993·Prostaglandins·C ChiabrandoR Fanelli
Jan 1, 1992·Trends in Cardiovascular Medicine·C PatronoG Ciabattoni
Nov 1, 1987·Journal of the American College of Cardiology·C W HammP C Weber
Jan 1, 1991·The American Review of Respiratory Disease·I K TaylorR W Fuller
Sep 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G Remuzzi, P Ruggenenti
Mar 3, 1998·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S YamanobeM Tamai
Jun 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R Lassila, K E Laustiola
Jan 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S E Barrow, J M Ritter
Jan 1, 1988·American Heart Journal·G A FitzGeraldJ Nowak
Dec 3, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·L Y Lee, J L Hong
Jun 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·C RångemarkA Wennmalm
Feb 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·A BröijersénP Hjemdahl
Jan 1, 1994·Progress in Lipid Research·U Diczfalusy
Oct 13, 1989·Biochimica Et Biophysica Acta·S E BarrowC T Dollery
Jan 28, 1991·Biochimica Et Biophysica Acta·W M UedelhovenP C Weber

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