PMID: 8466942Apr 7, 1993Paper

Formation of prostanoids and hydroxy fatty acids by stimulated peritoneal mast cells: role of the dietary fat type in rat

Biochimica Et Biophysica Acta
C M van HaasterG J van der Vusse

Abstract

To study the influence of membrane fatty acid composition on the formation of prostanoids and hydroxy fatty acids by rat peritoneal mast cells (MC), animals were fed three different types of fatty acids: mackerel oil (MO), abundant in n-3 fatty acids; sunflower seed oil (SO), rich in linoleic acid; and hydrogenated coconut oil (HCO), mainly containing saturated fatty acids. The presence of n-3 fatty acids in the diet resulted in the incorporation of 20:5(n-3), 22:5(n-3) and 22:6(n-3) in MC phospholipids. A decrease of arachidonic acid, 20:4(n-6), was observed in MC-phospholipids of the MO-fed animals. Furthermore, increasing the relative amounts of 18:2(n-6) in the diet (SO group) led to an increased incorporation of linoleic acid, 18:2(n-6) in MC phospholipids when compared to both other dietary groups. The changes in MC phospholipid fatty acid composition were (partly) reflected in the formation of prostanoids and hydroxy fatty acids upon stimulation with the calcium ionophore A23187. The decrease in arachidonic acid content in MC phospholipids of MO-fed rats resulted in a decreased formation of PGD2 when compared to both other groups. Also, the increased amounts of 18:2(n-6) in MC phospholipids of SO-fed rats resulted in an ...Continue Reading

References

May 15, 1979·European Journal of Pharmacology·C W Ogle, H K Lau
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P Borgeat, B Samuelsson
Oct 1, 1991·Trends in Biochemical Sciences·T Schewe, H Kühn
Mar 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M Y AbeywardenaJ S Charnock
May 17, 1991·European Journal of Pharmacology·P A HenricksF P Nijkamp
Jun 3, 1991·Biochimica Et Biophysica Acta·R C VossenR F Zwaal
Oct 1, 1988·The Journal of Investigative Dermatology·B A BurrallE J Goetzl
Aug 8, 1989·Biochimica Et Biophysica Acta·J W HeemskerkG Hornstra
Jan 1, 1986·Progress in Lipid Research·E A HiggsJ R Vane
Oct 23, 1985·Biochimica Et Biophysica Acta·M ClaeysD H Nugteren
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J E McGee, F A Fitzpatrick
Oct 1, 1986·Japanese Journal of Pharmacology·K TakeuchiS Okabe
Jan 1, 1984·Prostaglandins, Leukotrienes, and Medicine·J VerhagenP L Bruynzeel
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss
Jan 1, 1980·Journal of Immunological Methods·L Enerbäck, I Svensson
Nov 18, 2008·Cancer Research·Jessica L FlemingAmanda Ewart Toland

❮ Previous
Next ❯

Citations

Mar 15, 2015·Journal of Leukocyte Biology·Xiaofeng Wang, Marianna Kulka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.