Abstract
DNA damage by endogenous and exogenous agents is a serious concern, as the damaged products can affect genome integrity severely. Damage to DNA may arise from various factors such as DNA base modifications, strand break, inter- and intrastrand crosslinks, and DNA-protein crosslinks. Among these factors, DNA base modification is a common and important form of DNA damage that has been implicated in mutagenesis, carcinogenesis, and many other pathological conditions. Among the four DNA bases, guanine (G) has the smallest oxidation potential, because of which it is frequently modified by reactive species, giving rise to a plethora of lethal lesions. Similarly, 8-oxo-7,8-dihydroguanine (8-oxoG), an oxidatively damaged guanine lesion, also undergoes various degradation reactions giving rise to several mutagenic species. The various products formed from reactions of G or 8-oxoG with different reactive species are mainly 2,6-diamino-4-oxo-5-formamidopyrimidine, 2,5-diamino-4H-imidazolone, 2,2,4-triamino-5-(2H)-oxazolone, 5-guanidino-4-nitroimidazole, guanidinohydantoin, spiroiminodihydantoin, cyanuric acid, parabanic acid, oxaluric acid, and urea, among others. These products are formed from either ring opening or ring opening and subs...Continue Reading
References
Jun 25, 1992·Nucleic Acids Research·B TudekJ Laval
May 21, 1991·Biochemistry·Y NakamuraS Ohtaki
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J W Park, B N Ames
Jul 11, 1984·Nucleic Acids Research·S BoiteuxJ Laval
Feb 24, 1983·Nature·C S FooteR I Lehrer
Apr 1, 1997·Chemical Research in Toxicology·D R LloydP L Carmichael
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·S S MarlaJ T Groves
Mar 5, 1999·Mutation Research·J CadetS Sauvaigo
May 18, 1999·Chemical Research in Toxicology·N Y TretyakovaS R Tannenbaum
Jul 23, 1999·Mutation Research·B Halliwell
Dec 22, 1999·Proceedings of the Society for Experimental Biology and Medicine·A E Aust, J F Eveleigh
Mar 10, 2000·Nucleic Acids Research·V DuarteJ Cadet
May 17, 2000·Chemical Research in Toxicology·J C NilesS R Tannenbaum
Jul 18, 2000·Chemical Research in Toxicology·J P PougetJ Cadet
Aug 30, 2000·Toxicology·J P Kehrer
Jun 21, 2001·Journal of the American Chemical Society·A ChworosB Meunier
Jul 17, 2001·Chemical Research in Toxicology·W LuoC J Burrows
Sep 1, 2001·Organic Letters·W LuoC J Burrows
Dec 6, 2001·Journal of the American Chemical Society·J C NilesS R Tannenbaum
Feb 2, 2002·Chemistry : a European Journal·Lars T Burgdorf, Thomas Carell
Feb 13, 2002·The Journal of Biological Chemistry·Kenjiro AsagoshiHiroshi Ide
Feb 19, 2002·Chemical Reviews·Cynthia J. Burrows, James G. Muller
Mar 9, 2002·Nucleic Acids Research·Vadim I BruskovAnatoly V Chernikov
Apr 11, 2002·Journal of the American Chemical Society·Chimin SheuChristopher S Foote
May 7, 2002·Nature Reviews. Cancer·Laurence H Hurley
May 30, 2002·Nucleic Acids Research·Toshinori SuzukiHiroshi Ohshima
Jun 5, 2002·Biochemistry·Feng GuSteven R Tannenbaum
Jun 20, 2002·Journal of the American Chemical Society·Carissa J Wiederholt, Marc M Greenberg
Jul 11, 2002·Free Radical Biology & Medicine·Ryszard OlinskiPawel Jaruga
Dec 31, 2002·Toxicology·Lawrence J Marnett
Jan 25, 2003·Journal of Biochemistry and Molecular Biology·Barbara Tudek
Aug 13, 2003·Biochemistry·Carissa J WiederholtMarc M Greenberg
Aug 20, 2003·Chemical Research in Toxicology·Avrum JoffeVladimir Shafirovich
Oct 1, 1963·The Biochemical Journal·P D LAWLEY, P BROOKES
May 28, 1960·Nature·G HEMS
Jan 16, 2004·Organic Letters·William L NeeleyJohn M Essigmann
Jul 14, 2004·The Journal of Biological Chemistry·Franck CosteBertrand Castaing
Aug 3, 2004·Nature Reviews. Cancer·Miriam C Poirier
Aug 10, 2004·The Journal of Biological Chemistry·William L NeeleyJohn M Essigmann
Sep 3, 2004·Mutation Research·Mark D EvansMarcus S Cooke
Dec 22, 2004·Biochemistry·Rebecca A Perlow-PoehneltSuse Broyde
Dec 23, 2004·Journal of the American Chemical Society·Jeremy E B McCallumChristopher S Foote
Jan 18, 2005·Chemical Research in Toxicology·Paul T HendersonJohn M Essigmann
May 14, 2005·Free Radical Biology & Medicine·Glaucia R MartinezPaolo Di Mascio
Jun 29, 2005·Bioorganic & Medicinal Chemistry Letters·Sang Soo HahPaul T Henderson
Sep 15, 2005·Nucleic Acids Research·Sriram Kanvah, Gary B Schuster
Dec 3, 2005·Chembiochem : a European Journal of Chemical Biology·Adam KupanBernard Meunier
Dec 15, 2005·Nitric Oxide : Biology and Chemistry·Jacquin C NilesSteven R Tannenbaum
Dec 20, 2005·Chemical Research in Toxicology·Hongbin YuSteven R Tannenbaum
Dec 22, 2005·Journal of the American Chemical Society·Matthias OberThomas Carell
Citations
Jul 4, 2012·Journal of Biosciences·N R Jena
May 21, 2013·Nature Chemical Biology·Tim H GehrkeThomas Carell
Sep 21, 2013·Cancer Letters·Kristina GlebovaAncha Baranova
Nov 1, 2015·Nucleic Acids Research·Nicholas C BauerPaul W Doetsch
Feb 19, 2016·Journal of Agricultural and Food Chemistry·Marta RomeuMontserrat Giralt
Aug 13, 2013·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Nihar Ranjan Jena, Phool Chand Mishra
May 16, 2014·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Nihar R JenaPhool C Mishra
Nov 14, 2015·Archives of Toxicology·Ching-Fen WuThomas Efferth
Jun 24, 2015·Physical Chemistry Chemical Physics : PCCP·N R JenaP C Mishra
Apr 23, 2016·Physical Chemistry Chemical Physics : PCCP·N R JenaP C Mishra
Jan 24, 2015·DNA Repair·Shanqiao WeiAshok S Bhagwat
Dec 2, 2014·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Nirmallya AcharyyaSmarajit Maiti
Jan 24, 2013·Journal of the American Chemical Society·Denis I NilovR Marshall Wilson
Jul 24, 2013·The Journal of Physical Chemistry. B·Brian T Psciuk, H Bernhard Schlegel
Sep 2, 2016·Biochemistry·Safnas F AbdulSalamEdward J Merino
Aug 6, 2014·Bioorganic & Medicinal Chemistry·Joris IrvoasGeneviève Pratviel
Apr 25, 2017·Environmental and Molecular Mutagenesis·Yan ShaR Stephen Lloyd
Apr 1, 2018·Chemistry : a European Journal·Bruno Mattia BizzarriJuan Manuel García-Ruiz
Aug 16, 2017·Chembiochem : a European Journal of Chemical Biology·Safnas F AbdulSalamEdward J Merino
Nov 4, 2017·Oxidative Medicine and Cellular Longevity·Kazuya ShinmuraHaruhiko Sugimura
Aug 12, 2017·Scientific Reports·Peng LiuDunyou Wang
Jun 12, 2017·Journal of Molecular Biology·Anvesh DasariAnthony J Berdis
May 3, 2019·Archives of Biochemistry and Biophysics·Camila Aguilar DelgadoCarmen Regla Vargas
Oct 2, 2019·Chemical Research in Toxicology·Sebastien P Hebert, H Bernhard Schlegel
Mar 20, 2019·Analytical Chemistry·Casey A ChamberlainTimothy J Garrett
Mar 6, 2019·The Journal of Physical Chemistry. B·Yinghui WangHongmei Su