Formation of spatially discordant alternans due to fluctuations and diffusion of calcium

PloS One
Daisuke SatoYohannes Shiferaw

Abstract

Spatially discordant alternans (SDA) of action potential duration (APD) is a phenomenon where different regions of cardiac tissue exhibit an alternating sequence of APD that are out-of-phase. SDA is arrhythmogenic since it can induce spatial heterogeneity of refractoriness, which can cause wavebreak and reentry. However, the underlying mechanisms for the formation of SDA are not completely understood. In this paper, we present a novel mechanism for the formation of SDA in the case where the cellular instability leading to alternans is caused by intracellular calcium (Ca) cycling, and where Ca transient and APD alternans are electromechanically concordant. In particular, we show that SDA is formed when rapidly paced cardiac tissue develops alternans over many beats due to Ca accumulation in the sarcoplasmic reticulum (SR). The mechanism presented here relies on the observation that Ca cycling fluctuations dictate Ca alternans phase since the amplitude of Ca alternans is small during the early stages of pacing. Thus, different regions of a cardiac myocyte will typically develop Ca alternans which are opposite in phase at the early stages of pacing. These subcellular patterns then gradually coarsen due to interactions with membran...Continue Reading

References

Aug 1, 1968·Journal of Applied Physiology·J B Nolasco, R W Dahlen
Jan 27, 1994·The New England Journal of Medicine·David S RosenbaumR J Cohen
Dec 13, 1997·Circulation·G A Langer, A Peskoff
Mar 17, 1999·Circulation·Joseph M PastoreDavid S Rosenbaum
Sep 24, 1999·IEEE Transactions on Bio-medical Engineering·Zhilin Qu, Alan Garfinkel
Oct 26, 1999·Cardiovascular Research·D E Euler
Dec 10, 1999·Biophysical Journal·E ChudinB Kogan
Mar 10, 2001·Journal of Cardiovascular Electrophysiology·M A WatanabeAlain Karma
Jan 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Jeffrey J FoxRobert F Gilmour
Feb 15, 2002·Journal of Cardiovascular Electrophysiology·Steven M Pogwizd, Donald M Bers
May 15, 2002·Physical Review Letters·Blas Echebarria, Alain Karma
Mar 6, 2003·Cardiovascular Research·Mariah L Walker, David S Rosenbaum
Aug 2, 2003·Critical Reviews in Clinical Laboratory Sciences·William T Clusin
Dec 4, 2003·Biophysical Journal·Yohannes ShiferawA Karma
Jan 31, 2004·Circulation Research·Mary E DíazDavid A Eisner
Mar 24, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Yohannes ShiferawAlain Karma
Apr 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yohannes Shiferaw, Alain Karma
May 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stephan E LehnartAndrew R Marks
Jul 11, 2006·International Heart Journal·Yoshiyasu AizawaTohru Ohe
Aug 12, 2006·Circulation Research·Daisuke SatoAlain Karma
Oct 31, 2006·Biophysical Journal·Hideki HayashiZhilin Qu
Nov 30, 2006·Annals of the New York Academy of Sciences·Henk E D J ter KeursBruno D M Stuyvers
Oct 2, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jonathan M CordeiroJ Andrew Wasserstrom
Dec 7, 2007·Journal of Molecular and Cellular Cardiology·Kenneth R Laurita, David S Rosenbaum
Feb 1, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Blas Echebarria, Alain Karma
Apr 9, 2008·Progress in Biophysics and Molecular Biology·Kenneth R Laurita, David S Rosenbaum
Aug 5, 2008·Biophysical Journal·Juan G RestrepoAlain Karma
Jan 6, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Sandor Györke
Jul 25, 2009·Circulation Research·Stephen A GaetaDavid J Christini
Oct 20, 2009·Experimental Physiology·John H Coote
Mar 2, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Wei ChenYohannes Shiferaw
Mar 29, 2012·Advances in Experimental Medicine and Biology·Qing LouIgor R Efimov
Apr 3, 2012·Physical Review Letters·Per Sebastian SkardalJuan G Restrepo
Jul 12, 2012·Frontiers in Physiology·Stephen A Gaeta, David J Christini

Citations

Jul 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Thomas QuailLeon Glass
Apr 2, 2015·Journal of Molecular and Cellular Cardiology·Karin P HammerDonald M Bers
Dec 2, 2014·Journal of Theoretical Biology·Ning WeiElena G Tolkacheva
Oct 21, 2016·Journal of Arrhythmia·Gary TseJie Ming Yeo
Jun 16, 2016·Journal of Theoretical Biology·Justin EastmanElizabeth M Cherry
Aug 23, 2016·Journal of Molecular and Cellular Cardiology·Pei-Chi YangColleen E Clancy
Dec 2, 2016·The Journal of Physiology·Matthew KennedyDaisuke Sato
Aug 12, 2017·Scientific Reports·Marcel HörningKenichi Yoshikawa
Feb 25, 2020·Circulation Research·Pei-Chi YangColleen E Clancy
May 26, 2020·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Matthew J Hoffman, Elizabeth M Cherry
Jul 2, 2017·Medicina·Giedrius Kanaporis, Lothar A Blatter
Jan 18, 2018·PLoS Computational Biology·Daisuke SatoManuel F Navedo
Oct 30, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Per Sebastian SkardalJuan G Restrepo
Mar 22, 2021·Frontiers in Physiology·Tingting YouHenggui Zhang

Related Concepts

alternan
Nerve Impulses
Calcium
Diffusion
Polycose
Sarcomeres
Myocytes, Cardiac
Space-Time Geography
Action Potentials
Sarcoplasmic Reticulum

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