Formation of the Dictyostelium spore coat

Developmental Genetics
C M West, G W Erdos

Abstract

The spore coat forms as a rigid extracellular wall around each spore cell during culmination. Coats purified from germinated spores contain multiple protein species and an approximately equal mass of polysaccharide, consisting mostly of cellulose and a galactose/N-acetylgalactosamine polysaccharide (GPS). All but the cellulose are prepackaged during prespore cell differentiation in a regulated secretory compartment, the prespore vesicle. The morphology of this compartment resembles an anastomosing, tubular network rather than a spherical vesicle. The molecules of the prespore vesicles are not uniformly mixed but are segregated into partially overlapping domains. Although lysosomal enzymes have been found in the prespore vesicle, this compartment does not function as a lysosome because it is not acidic, and a common antigen associated with acid hydrolases is found in another, acidic vesicle population. All the prespore vesicle profiles disappear at the time of appearance of their contents outside of the cell; this constitutes an early stage in spore coat formation, which can be detected both by microscopy and flow cytometry. As an electron-dense layer, the future outer layer of the coat, condenses, cellulose can be found and is ...Continue Reading

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Citations

Dec 18, 1995·Experientia·M R Wilkins, K L Williams
Jan 1, 1993·Biology of the Cell·P FouchetG Frelat
May 10, 2000·Trends in Cell Biology·S SrinivasanS Alexander
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Dec 12, 2012·The Korean Journal of Parasitology·Eun-Kyung Moon, Hyun-Hee Kong
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Jul 19, 2000·Developmental Biology·K Y Gregg, E C Cox
Jun 29, 2001·Differentiation; Research in Biological Diversity·P ZhangC M West

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