Formation of thermo-sensitive polyelectrolyte complex micelles from two biocompatible graft copolymers for drug delivery

Journal of Biomedical Materials Research. Part a
Guiying LiJunshen Liu

Abstract

Thermo-sensitive polyelectrolyte complex (PEC) micelles assembled from two biocompatible graft copolymers chitosan-g-poly(N-isopropylacrylamide) (CS-g-PNIPAM) and carboxymethyl cellulose-g-poly(N-isopropylacrylamide) (CMC-g-PNIPAM) were prepared for delivery of 5-fluorouracil (5-FU). The PEC micelles showed a narrow size distribution with core-shell structure, in which the core formed from positively charged CS and negatively charged CMC by electrostatic interactions and the shell formed from thermo-sensitive PNIPAM. The synthesized PEC micelles have lower critical solution temperatures (LCST) in the region of 37°C, which is favorable for smart drug delivery applications. The hydrogen bondings between PEC micelles and 5-FU increased the drug loading. Changing temperature, pH or ionic strength, a sustained and controlled release was observed due to the deformation of PEC micelles. Adding glutaraldehyde, a chemical crosslinking reagent, was an efficient way to reinforce the micelles structure and decrease the initial burst release. Cytotoxicity assays showed that drug-loaded PEC micelles retained higher cell inhibition efficiency in HeLa cells.

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Citations

Jan 26, 2016·International Journal of Biological Macromolecules·Nana YuQian Tao
May 4, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kadi-Liis VeimanKaido Kurrikoff
May 6, 2014·Frontiers in Pharmacology·Aditi M Jhaveri, Vladimir P Torchilin
Jun 29, 2016·ACS Applied Materials & Interfaces·Mahdi KarimiMichael R Hamblin
Dec 8, 2017·Archives of Pharmacal Research·Hima Bindu RuttalaJong Oh Kim
Feb 21, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Balaram Ghosh, Swati Biswas
Mar 14, 2021·Colloids and Surfaces. B, Biointerfaces·Yuhan YanChunguang Ren

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