Formation of Tubulovesicular Carriers from Endosomes and Their Fusion to the trans-Golgi Network

International Review of Cell and Molecular Biology
Aitor HierroJ S Bonifacino

Abstract

Endosomes undergo extensive spatiotemporal rearrangements as proteins and lipids flux through them in a series of fusion and fission events. These controlled changes enable the concentration of cargo for eventual degradation while ensuring the proper recycling of other components. A growing body of studies has now defined multiple recycling pathways from endosomes to the trans-Golgi network (TGN) which differ in their molecular machineries. The recycling process requires specific sets of lipids, coats, adaptors, and accessory proteins that coordinate cargo selection with membrane deformation and its association with the cytoskeleton. Specific tethering factors and SNARE (SNAP (Soluble NSF Attachment Protein) Receptor) complexes are then required for the docking and fusion with the acceptor membrane. Herein, we summarize some of the current knowledge of the machineries that govern the retrograde transport from endosomes to the TGN.

Citations

Jul 22, 2016·Molecular Biology of the Cell·David C GershlickJuan S Bonifacino
May 13, 2020·Communicative & Integrative Biology·Syara FujiiAkiko K Satoh
Mar 21, 2018·Molecular and Cellular Biology·Juan F ArandaCarlos Fernández-Hernando
Dec 13, 2017·Proceedings of the National Academy of Sciences of the United States of America·Miguel Romano-MorenoAitor Hierro
Nov 27, 2020·Nature Communications·John J H ShinSean Munro
Dec 3, 2020·Journal of Cell Science·Syara FujiiAkiko K Satoh
Nov 2, 2016·Journal of Cell Science·Cinzia Progida, Oddmund Bakke

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