Formation of Zirconium(IV)-Heparin Complex Multilayers on Solid Surfaces for Long-Lasting Antiplatelet Application

Macromolecular Bioscience
Yeonwoo Jeong, Sung Min Kang

Abstract

A facile approach to enhancing the blood compatibility of solid surfaces based on ZrIV -heparin complexation is reported. Solid surfaces are pretreated with tannic acid (TA)/ZrIV complexes. Heparin is then deposited on the surface through a spin-coating process and fixed by a ZrIV -mediated crosslinking reaction. Using this approach, TA/ZrIV /heparin complex multilayers that are highly resistant to human platelet adhesion are formed on various substrates including metal, metal oxides, ceramics, and synthetic polymers. This approach presents a sustainable way for the immobilization of heparin onto surfaces because it does not require any derivatization of heparin molecule as well as time-consuming processes.

References

Nov 1, 1988·Journal of Biomedical Materials Research·K D ParkS W Kim
Nov 1, 1987·Biomaterials·C ArnanderJ Swedenborg
Apr 1, 1985·Journal of Biomedical Materials Research·P W HeymanS W Kim
Jan 1, 1996·Journal of Biomaterials Science. Polymer Edition·C J van DeldenJ Feijen
Oct 21, 2003·Journal of Biomedical Materials Research. Part a·Jonas AnderssonRolf Larsson
Jun 28, 2005·Colloids and Surfaces. B, Biointerfaces·Anfeng WangK Y Simon Ng
Aug 27, 2005·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Tatineni Balaji, Hideyuki Matsunaga
Jan 11, 2007·Journal of Materials Science. Materials in Medicine·Daniel AronovGil Rosenman
Jul 4, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Oju JeonByung-Soo Kim
Nov 11, 2009·Chemistry : a European Journal·In-Cheol SunCheol-Hee Ahn
Nov 8, 2011·Annual Review of Materials Research·Bruce P LeeJ H Waite
Mar 6, 2012·Journal of Materials Science. Materials in Medicine·In-Ho BaeMyung Ho Jeong
Apr 10, 2012·Medical & Biological Engineering & Computing·D Davidson JebaseelanRishi M Kanna
Jul 1, 2014·Chemical Communications : Chem Comm·Joseph E MondlochOmar K Farha

❮ Previous
Next ❯

Citations

Jun 2, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Yeonwoo Jeong, Sung Min Kang
Nov 18, 2020·Biomacromolecules·Dahee Kim, Sung Min Kang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.