Formation sites and distribution of osteoclast progenitor cells during the ontogeny of the mouse

Developmental Biology
C W Thesingh

Abstract

The presence of osteoclast progenitor cells in embryonic, fetal, young growing, and adult murine tissues and organs was investigated in a coculture system with fetal metatarsal bones stripped of periosteum and not yet invaded by osteoclasts. Osteoclasts were found to originate from the early yolk sac and from every tissue tested in the fetus and young mouse. In the adult mouse they were formed only from tissues with a large mononuclear phagocyte population. No osteoclasts could be generated from the young embryo proper, prior to establishment of the vascular connection with the yolk sac. Progenitors of osteoclasts or their stem cells therefore do not develop from undifferentiated mesenchyme outside the yolk sac, but are distributed from the yolk sac to embryonic tissues and hematopoietic organs through the vascular circulation. The embryonic distribution of osteoclast progenitors coincides with the distribution of immature macrophages. Furthermore, they are present before the formation of monocytes in the fetus. The results also indicate that osteoclast precursor cells are not identical with mature, differentiated macrophages, but are cells with little capacity to phagocytose and therefore are, at the most immature progenitors ...Continue Reading

References

Apr 1, 1978·Developmental and Comparative Immunology·T A Andrew, J J Owen
Jan 1, 1985·Calcified Tissue International·M A HortonT J Chambers
Aug 30, 1967·Journal of Ultrastructure Research·B L Scott
Dec 1, 1984·The Journal of Cell Biology·E H BurgerP J Nijweide
Apr 1, 1982·Immunobiology·J F Loutit, N W Nisbet
Dec 1, 1982·The Journal of Experimental Medicine·E H BurgerR van Furth
Feb 14, 1980·Nature·P AshK M Townsend
Aug 1, 1962·The Anatomical Record·D A FISCHMAN, E D HAY

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Citations

Feb 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D A Collins, T J Chambers
Feb 1, 1989·Calcified Tissue International·B Bar-Shira-MaymonM Silbermann
Jan 1, 1991·Electron Microscopy Reviews·A M PierceL Hammarström
May 1, 1993·Biological Reviews of the Cambridge Philosophical Society·M ZaidiM Pazianas
Aug 1, 1990·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·K Smetana, M Holub
Jan 1, 1991·Pathology, Research and Practice·M H ZhengJ M Papadimitriou
Feb 22, 2005·Archives of Oral Biology·Miep H Helfrich
Oct 1, 1987·Experimental and Molecular Pathology·K SmetanaZ Krcová
Sep 14, 2016·Journal of Anatomy·Christopher G Mueller, Benjamin Voisin
Jun 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M H HelfrichC W Thesingh
Apr 13, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kiyoshi Kanazawa, Akira Kudo
Sep 1, 1988·The American Journal of Anatomy·S C Marks, S N Popoff
Sep 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C E HagenaarsP J Nijweide
Jul 1, 1996·The Journal of Bone and Joint Surgery. American Volume·N A Athanasou
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shin-Ichi HayashiHidetoshi Yamazaki
Mar 9, 2021·Frontiers in Cell and Developmental Biology·Wen Hao NeoGeorges Lacaud

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