Formosins A-F: Diterpenoids with Anti-microbial Activities from Excoecaria formosana

Natural Products and Bioprospecting
Bing-Dong LinJian-Min Yue

Abstract

Three new halimane-type diterpenoids formosins A-C (1-3), and three clerodane-type diterpenoids formosins D-F (4-6), were isolated from the twigs of Excoecaria formosana. Their structures were assigned on the basis of spectroscopic data analysis. Compounds 1 and 4 showed moderate anti-microbial activities against Bacillus subtilis (MIC = 50 and 50 μg/mL, respectively). Compound 6 exhibited moderate anti-microbial activities against two strains of Helicobacter pylori (Hp-SS1 and ATCC 43504) with MIC values of 50 and 50 μg/mL, respectively.

References

Oct 22, 1998·Biological & Pharmaceutical Bulletin·T KonishiT Konoshima
Dec 5, 1998·The Australasian Journal of Dermatology·S P Kumarasinghe, R Seneviratne
Apr 11, 2000·Journal of Natural Products·T KonishiS Kiyosawa
Nov 27, 2001·Bioorganic & Medicinal Chemistry Letters·S P Yang, J M Yue
Jan 25, 2003·Journal of Natural Products·Tenji KonishiKazumoto Miyahara
Feb 7, 2004·Planta medica·Sophon RoengsumranAmorn Petsom
Dec 6, 2005·Chemical & Pharmaceutical Bulletin·Phan Minh GiangHideaki Otsuka
Jan 23, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhan Chang WangJun De Chen

❮ Previous
Next ❯

Citations

Apr 28, 2018·Natural Product Reports·Alejandro M RonceroIsidro S Marcos
Sep 15, 2018·Chemical Biology & Drug Design·Romina J RonchiMarianela Sánchez
Apr 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ho-Cheng WuHsun-Shuo Chang

❮ Previous
Next ❯

Methods Mentioned

BETA
NMR
column chromatography

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Natural Products
Jiangnan PengSusan L Mooberry
Journal of Natural Products
Patrícia RijoBenjamín Rodríguez
Journal of Natural Products
Hong-Bing LiuJian-Min Yue
© 2021 Meta ULC. All rights reserved