Formula for Unsilencing Plasticity: Spike with GABA

Neuron
Philip KesnerEdward S Ruthazer

Abstract

A complication for developmental plasticity mechanisms like spike-timing-dependent plasticity (STDP) is that immature postsynaptic neurons may lack sufficient input to fire action potentials. In this issue, van Rheede et al. (2015) report an activity-dependent mechanism that converts non-spiking cells into spiking neurons, priming them for further plasticity.

Citations

Feb 13, 2016·Nature Reviews. Neuroscience·Nicolas X TritschBernardo L Sabatini

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