Formulants of glyphosate-based herbicides have more deleterious impact than glyphosate on TM4 Sertoli cells

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Alison VanlaeysC Travert

Abstract

Roundup and Glyphogan are glyphosate-based herbicides containing the same concentration of glyphosate and confidential formulants. Formulants are declared as inert diluents but some are more toxic than glyphosate, such as the family of polyethoxylated alkylamines (POEA). We tested glyphosate alone, glyphosate-based herbicide formulations and POEA on the immature mouse Sertoli cell line (TM4), at concentrations ranging from environmental to agricultural-use levels. Our results show that formulations of glyphosate-based herbicides induce TM4 mitochondrial dysfunction (like glyphosate, but to a lesser extent), disruption of cell detoxification systems, lipid droplet accumulation and mortality at sub-agricultural doses. Formulants, especially those present in Glyphogan, are more deleterious than glyphosate and thus should be considered as active principles of these pesticides. Lipid droplet accumulation after acute exposure to POEA suggests the rapid penetration and accumulation of formulants, leading to mortality after 24 h. As Sertoli cells are essential for testicular development and normal onset of spermatogenesis, disturbance of their function by glyphosate-based herbicides could contribute to disruption of reproductive functi...Continue Reading

Citations

Sep 9, 2020·Journal of Immunotoxicology·Cindy Peillex, Martin Pelletier
Jul 6, 2019·Ecotoxicology and Environmental Safety·Líria Queiroz Luz HiranoLucélia Gonçalves Vieira
Apr 2, 2021·Frontiers in Endocrinology·Anderson Tadeu de Araújo-RamosAnderson Joel Martino-Andrade
Jul 14, 2020·Molecular and Cellular Endocrinology·Paola IngaramoEnrique H Luque
Jun 6, 2021·Toxicology and Applied Pharmacology·A S VallésN E Furland
Jun 8, 2021·Frontiers in Endocrinology·María Florencia RossettiJorge Guillermo Ramos
Jun 22, 2021·Toxicology Reports·Valeriya P KalyabinaValentina A Kratasyuk
Nov 28, 2021·International Journal of Molecular Sciences·Marianna MarinoAntonietta Santoro
Dec 28, 2021·International Journal of Food Sciences and Nutrition·Dayan Carvalho Ramos Salles de OliveiraEliseu Verly-Jr
Dec 30, 2021·Journal of Biochemical and Molecular Toxicology·Jitender K BhardwajSom N Sachdeva

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