PMID: 20635831Jul 20, 2010Paper

Formulary review of 2 new biologic agents: tocilizumab for rheumatoid arthritis and ustekinumab for plaque psoriasis

Journal of Managed Care Pharmacy : JMCP
Jeremy A SchaferPatrick P Gleason

Abstract

Two autoimmune biologics were recently approved by the FDA: ustekinumab in September 2009 for the treatment of moderate to severe plaque psoriasis in adults who are candidates for phototherapy or systemic therapy and tocilizumab in January 2010 for adult patients with moderate to severe rheumatoid arthritis (RA) who have not responded adequately to 1 or more tumor necrosis factor (TNF) antagonist therapies. Both agents use new mechanisms of action and add to the growing group of autoimmune biologics. To critically review the phase 3 trials for ustekinumab and tocilizumab and provide managed care considerations in the context of the 9 other biologic agents on the market in the United States that are used to treat moderate to severe RA or psoriasis. A MEDLINE review was performed for articles published and available through January 2010 using keywords "ustekinumab" and "tocilizumab" with an emphasis on phase 3 trials. The literature search was limited to articles in English, clinical trials, randomized controlled trials, and research conducted in humans. Search results for ustekinumab included 8 articles of which 4 were excluded for not being psoriasis or psoriatic arthritis trials. Search results for tocilizumab included 16 arti...Continue Reading

Citations

Mar 24, 2018·Cardiology in Review·Vincent J Mariano, William H Frishman
Oct 25, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Susanne KarbachThomas Münzel
Mar 26, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masaaki HiuraMasaru Harada
Jul 9, 2011·Expert Opinion on Pharmacotherapy·Jonathan P StaidleSteven R Feldman

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