Formulation and advantages of furazolidone in liposomal drug delivery systems

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Muhammad Irfan AlamAmal Ali Elkordy

Abstract

Furazolidone has proven to have antiprotozoal and antibacterial activity. A number of literature supported its use against Helicobacter pylori. This potential application opens new prospects of its use in clinical settings in triple therapy. In order to avoid side effects associated with this drug, liposomal mucoadhesive drug delivery that can work locally in stomach is considered as an appropriate approach. This study is a focus on formulations and in vitro characterization of liposomes containing furazolidone. Therefore, the effects of variable amounts of drug and cholesterol on encapsulation efficacy and in vitro drug release were evaluated for different liposomal formulations. Mucoadhesive behavior of chitosan coated liposomal at two different pHs was also evaluated and increase in pH from 1.3 to 4.5 increased mucoadhesion from 42% to 60% respectively. Increasing the amount of drug from 4mg to 5mg increased encapsulation activity however, increasing the drug any further decreased encapsulation activity. In contrast, by increasing the amount of cholesterol decrease in encapsulation activity was observed. The optimized formulation with 5mg of drug and 53mg of cholesterol in formulation gave 57% drug release at pH 1.3 but rele...Continue Reading

References

Nov 27, 1990·Biochemistry·M B Sankaram, T E Thompson
Oct 9, 1998·Gut·D ScottG Sachs
Feb 3, 2004·The Journal of Clinical Investigation·Martin J Blaser, John C Atherton
Aug 29, 2007·International Journal of Nanomedicine·Katherine Bowman, Kam W Leong
Nov 22, 2007·Journal of Applied Microbiology·E A O'GaraD J Hill
Jan 10, 2009·Advanced Drug Delivery Reviews·Samuel K LaiJustin Hanes
May 22, 2009·Gastroenterology·Timothy L Cover, Martin J Blaser
Jun 30, 2009·International Journal of Pharmaceutics·Ning LiWeisan Pan
Aug 18, 2009·Acta Ophthalmologica·Fawzia S HabibDina Fathalla
Jul 6, 2010·International Journal of Pharmaceutics·Ghada M El ZaafaranyNahed D Mortada
Jul 19, 2008·Annual Review of Analytical Chemistry·Aldo Jesorka, Owe Orwar
Sep 21, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Johannes ParmentierGert Fricker
Oct 22, 2010·Drug Development and Industrial Pharmacy·Pankaj Ranjan KarnNataša Skalko-Basnet
Jan 4, 2012·Advanced Drug Delivery Reviews·Laura M EnsignJustin Hanes
Apr 24, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hyo-Kyung HanDong Hoon Ha

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Citations

Aug 25, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chongshan DaiShusheng Tang
Oct 25, 2016·Future Medicinal Chemistry·Shaghayegh Fathi, Adegboyega K Oyelere
Feb 16, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Y Lee, D H Thompson
Aug 18, 2020·Drug Delivery and Translational Research·Suzana Gonçalves CarvalhoJanaína Cecília Oliveira Villanova
Jun 24, 2018·Research in Veterinary Science·Suzana Gonçalves CarvalhoJanaina Cecília Oliveira Villanova

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