Formulation and Characterization of α-Mangostin in Chitosan Nanoparticles Coated by Sodium Alginate, Sodium Silicate, and Polyethylene Glycol

Journal of Pharmacy & Bioallied Sciences
Nasrul WathoniMuchtaridi Muchtaridi

Abstract

α-mangostin, one of the xanthone derivative compounds isolated from Garcinia mangostana L. peel extract, has an excellent anticancer efficacy. However, α-mangostin has a lack of site specificity, poor cells selectivity, and low aqueous solubility. Polymeric nanoparticles formulation can be used to solve these problems. Therefore, the main aim of this study was to develop polymeric nanoparticles of α-mangostin-based chitosan (αM-Ch) coated by sodium alginate (αM-Ch/Al), sodium silicate (αM-Ch/Si), and polyethylene glycol 6000 (αM-Ch/PEG). Polymeric nanoparticles were prepared by ionic gelation method with the spray pyrolysis technique. Optimized formula was characterized by scanning electron microscopy, particle size, entrapment efficiency, drug loading, Fourier transform infrared, X-ray diffraction (XRD), and differential scanning calorimetry (DSC). αM-Ch/Al, αM-Ch/Si, and αM-Ch/PEG Nanoparticles were successfully prepared with the range of particle size approximately 200-400nm. The XRD patterns and DSC thermograms of αM-Ch/Al showed an amorphous state, whereas αM-Ch/Si and αM-Ch/PEG indicated low crystalline forms. In addition, αM-Ch/Al had the highest entrapment efficiency (98.33% ± 0.06%) compared to αM-Ch/Si (70.46% ± 8.93%...Continue Reading

References

Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·S MitraA N Maitra
Aug 23, 2003·Journal of Natural Products·Kenji MatsumotoYoshinori Nozawa
Oct 4, 2003·Physical Review Letters·K K NandaS Stappert
Mar 10, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Alireza GhaffariMorteza Rafiee-Tehrani
Apr 1, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Xiangrong SongQiuhong Chen
Jun 30, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·G SaravanakumarIck Chan Kwon
Jun 11, 2010·Journal of Materials Science. Materials in Medicine·Naveen K ThakralDipak K Majumdar
Apr 25, 2012·Annual Review of Biomedical Engineering·Alexandre AlbaneseWarren C W Chan
Sep 18, 2012·Biochimica Et Biophysica Acta·Jun-Jie KohRoger W Beuerman
Sep 22, 2012·Acta Biomaterialia·Frederico NogueiraM Cristina L Martins
Jan 22, 2013·International Journal of Pharmaceutics·Biswadip SinhaJan P Möschwitzer
Dec 27, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Farha Masood
Feb 12, 2017·International Journal of Biological Macromolecules·Thandapani GomathiSukumaran Anil
Dec 1, 2015·Journal of Food and Drug Analysis·M Abd ElgadirMd Zaidul Islam Sarker
Jul 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ali GhasemzadehAmin Tayebi-Meigooni

❮ Previous
Next ❯

Methods Mentioned

BETA
flow titration
scanning electron microscopy
differential scanning calorimetry
infrared
infrared spectroscopy
X-ray

Software Mentioned

Image J
TA
Origin
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.