Formulation and characterization of a covalently coated magnetic nanogel.

Journal of Nanoscience and Nanotechnology
Maham RahimiKytai Nguyen

Abstract

The aim of this study was to develop a novel method to encapsulate magnetic nanoparticles (MNPs) with polymer via covalent bonding, in order to increase the magnetic nanoparticle stability and ease the synthesis process. In this technique, silane coated MNPs act as a template for polymerization of the monomer N-isopropylacrylamide, (NIPA) via radical polymerization. Transmission and scanning electron microscopy indicated the size of the original MNP was approximately 10 nm, the silane-coated MNP was 40 nm and the NIPA silane-coated MNP was 100 +/- 10 nm. Chemical composition and chemical state analysis of NIPA MNPs by FTIR and XPS showed that the MNPs were actually encapsulated by silane and NIPA. Furthermore, the magnetic properties of different layers on the MNP, analyzed by SQUID, indicated a decrease in saturation magnetization for each layer. The results demonstrate the feasibility of encapsulation of the MNP with NIPA by means of silane covalent bonding. Future work will investigate the phase transition and biocompatibility properties of the NIPA-coated MNP for drug delivery and tissue engineering applications.

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Citations

Feb 23, 2010·Nanomedicine : Nanotechnology, Biology, and Medicine·Maham RahimiKytai Truong Nguyen
Nov 1, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Priya RavikumarConnie C W Hsia
Jun 12, 2013·Biotechnology Advances·L BorlidoM R Aires-Barros
Mar 13, 2014·International Journal of Pharmaceutics·Varsha SundaresanAniket S Wadajkar
Dec 8, 2010·Circulation·Lilei YuSunny S Po
Oct 13, 2012·Advanced Healthcare Materials·Aniket S WadajkarJian Yang
Feb 4, 2021·Bioengineering & Translational Medicine·Baeckkyoung SungLeon Abelmann
Oct 29, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Natalia FrickelAnnette M Schmidt

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