Formulation and characterization of calcium alginate beads containing ampicillin

Pharmaceutical Development and Technology
M L TorreU Conte

Abstract

The purpose of this work was the preparation and characterization of calcium alginate beads containing ampicillin. Aqueous solutions of drug and sodium alginate (three viscosity grades) were added drop by drop to aqueous solutions of calcium chloride; the droplets instantaneously formed gel beads, which were then dried. Morphological studies and drug contents, in vitro release, and erosion tests were carried out for the characterization of the prepared beads. The dried particles were characterized by irregular shape and a smooth or rough surface, depending on the viscosity grade of the alginate used. The control of the drug for different time intervals depended on the molecular weight of the polymer used; however, the pH-change test showed that this capacity was much lower in the case of acid-treated particles. The results obtained show that the ampicillin beads prepared are suitable for intramammary therapy.

References

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Citations

Oct 6, 2009·Chemical & Pharmaceutical Bulletin·Paruvathanahalli Siddalingam Rajinikanth, Brahmeshwar Mishra
Feb 21, 2002·Pharmaceutical Development and Technology·Manuel Efentakis, Graham Buckton
Oct 12, 2000·Drug Development and Industrial Pharmacy·T R BhardwajA Gupta
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Jul 10, 2016·International Journal of Biological Macromolecules·A M OmerN Koseva

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