Formulation and characterization of Phospholipon 90 G and tween 80 based transfersomes for transdermal delivery of eprosartan mesylate

Pharmaceutical Development and Technology
Abdul AhadMohd Aftab Alam

Abstract

The objective of the current study was to formulate the eprosartan mesylate loaded transfersomes using different proportions of Phospholipon® 90 G and Tween® 80 (95-75:5-25% w/w). The prepared transfersomes were characterized for their vesicles size, shape, polydispersity index, zeta potential, entrapment efficiency, in vitro skin permeation, confocal laser scanning microscopy, and in vivo skin irritation. Results revealed that the formulated transfersomes were negatively charged, spherical unilamellar structure of 71.18-85.66 nm with entrapment efficiency of 83.00-88.19%, and presented transdermal flux of 1.78-5.02 μg/cm2/h across rat skin. Confocal laser scanning microscopy confirmed that the formulated rhodamine 6 G loaded transfersomes could penetrate deeply and uniformly into rat skin. Additionally, in vivo skin irritation studies revealed that the prepared transfersomes were devoid of any skin irritation potential (erythema and edema). Results of this study revealed that the transfersomes prepared with Tween® 80 could be used to enhance the transdermal delivery of eprosartan mesylate. In conclusion, transdermal transfersomes formulation may prove to be an encouraging drug carrier for eprosartan mesylate and other actives,...Continue Reading

References

Feb 17, 2000·International Journal of Pharmaceutics·G M El MaghrabyB W Barry
Jun 15, 2000·Journal of Human Hypertension·Z H Israili
May 20, 2003·International Journal of Pharmaceutics·D D VermaA Fahr
Nov 24, 2004·Colloids and Surfaces. B, Biointerfaces·L B LopesA G Oliveira
Sep 20, 2005·Journal of Inorganic Biochemistry·Michael SharaDebasis Bagchi
Sep 9, 2006·Journal of Pharmaceutical Sciences·Dinesh MishraN K Jain
Oct 28, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lingyun XuXiangliang Yang
Jul 6, 2010·International Journal of Pharmaceutics·Ghada M El ZaafaranyNahed D Mortada
Oct 6, 2012·Therapeutic Delivery·Sevgi Güngör, Yildiz Ozsoy
Oct 16, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amit AlexanderDulal Krishna Tripathi
Aug 13, 2013·Journal of Photochemistry and Photobiology. B, Biology·Dan LiuXiaojun Shi
Aug 31, 2013·International Journal of Nanomedicine·Shu MengJianxin Li
Oct 15, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Shu LiuAkira Yamamoto
Mar 29, 2014·Drug Development and Industrial Pharmacy·Mohammed M MehannaMagda W Samaha
Apr 1, 2005·Drug Discovery Today. Technologies·P Loan Honeywell-Nguyen, Joke A Bouwstra
Mar 2, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ahmed H Al ShuwailiAlaa A Abdulrasool
Aug 20, 2016·International Journal of Nanomedicine·Alam ZebJin-Ki Kim
Sep 14, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mukul AshtikarAlfred Fahr

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Citations

Feb 19, 2019·Pharmaceutical Development and Technology·Dina Mahmoud MostafaGamal Awad
Jan 31, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Bivek ChaulagainSanjay K Jain
Feb 6, 2020·Journal of Oleo Science·Luis A González-OrtegaHugo S García
Dec 8, 2019·Drug Delivery and Translational Research·Juan J CarrerasAna Melero
Feb 16, 2021·Therapeutic Delivery·Rachana Sapkota, Alekha K Dash
Jul 28, 2020·Current Drug Delivery·Farzana AnjumZeenat Iqbal
Aug 29, 2021·Pharmaceutics·Nayyer IslamMohammed A S Abourehab

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