Formulation and evaluation of a protein-loaded solid dispersions by non-destructive methods.

The AAPS Journal
Ziyaur RahmanMansoor Khan

Abstract

The purpose of this investigation was to develop solid dispersion (SD) formulation of cyclosporine (CyA) using polyethylene glycol (PEG-6000) to enhance its dissolution rate followed by nondestructive method for the prediction of both drug and carrier. SD formulations were prepared by varying the ratio of CyA and PEG-6000 by solvent evaporation technique and characterized by dissolution, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR), powder X-ray diffraction (PXRD), near infrared (NIR) and near infrared chemical imaging (NIR-CI). Dissolution data revealed enhanced dissolution of CyA when compared with pure CyA. DSC results showed that the crystallinity of PEG-6000 has decreased as indicated by decrease in the enthalpy of fusion and melting peak in the formulations. FTIR data demonstrated no chemical interaction between drug and carrier. The surface morphology of SD formulations was similar to PEG-6000 particle. NIR-CI disclosed homogeneity of SD matrix as indicated by symmetrical histograms with smaller values of skewness. Similar to NIR, a multivariate peak evaluation with principal component analysis and partial least square (PLS) were carried out with PXRD spec...Continue Reading

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Citations

Sep 3, 2013·International Journal of Pharmaceutics·Ziyaur Rahman, Mansoor A Khan
May 21, 2011·AAPS PharmSciTech·Ziyaur RahmanMansoor A Khan
Feb 2, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Melissa GuadaMaria J Blanco-Prieto
Dec 15, 2015·International Journal of Pharmaceutics·Yi LiCarl A Anderson
May 18, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ziyaur RahmanMansoor A Khan
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Samixa DesaiKrutika Sawant

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