Formulation and evaluation of novel glycyrrhizic acid micelles for transdermal delivery of podophyllotoxin

Drug Delivery
Ya-Tian WangGuo-Feng Li

Abstract

As the first-line agent for genital warts, podophyllotoxin (POD) could induce extensively skin burning, itching, and erythema. Meanwhile, as a common anti-inflammatory agent, glycyrrhizic acid (GA), also has amphipathic and solubilizing properties, indicating that it might be a promising drug carrier. The objective of this study is to formulate and characterize the POD-loaded GA micelles preparation and to evaluate its drug release characteristics and anti-inflammatory properties. The novel micelles preparation was prepared by ultrasonic dispersion method and characterized using different scanning calorimetries, dynamic light scattering, and transmission electron microscopies. Subsequently, its encapsulation efficiency (EE), drug-loading content (LC), in vitro skin permeation, in vivo drug retention, and distribution of POD were detected. The anti-inflammatory effect of the preparation was reflected by HE staining and immunohistochemistry in the rat skin. The POD-loaded GA micelles formed spherical shapes (approximately 10 nm) with an EE of 78.53 ± 2.17% and a LC of 7.293 ± 0.42%. Meaningfully, unlike the extensive distribution of the POD tincture throughout the skin tissue, POD released from the POD-loaded GA micelles mainly l...Continue Reading

References

Jan 1, 1995·Dermatology : International Journal for Clinical and Investigative Dermatology·T A SyedS A Ahmad
Dec 9, 1998·European Journal of Morphology·T Hermanns-LêG E Piérard
Jan 15, 2003·Clinical Microbiology Reviews·Eileen M Burd
Aug 7, 2003·Sexually Transmitted Infections·C J N LaceyUNKNOWN Perstop Pharma Genital Warts Clinical Trial Group
Feb 19, 2004·Archives of Pharmacal Research·Hae-Young ParkDong-Hyun Kim
Mar 17, 2004·Advanced Drug Delivery Reviews·Adrian C Williams, Brian W Barry
Aug 11, 2004·Toxicon : Official Journal of the International Society on Toxinology·M GordalizaM A Gómez-Zurita
Aug 26, 2004·Dermatologic Therapy·David E Cohen, Noushin Heidary
Sep 3, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·R Alvarez-RománH Fessi
Dec 6, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Huabing ChenXiangliang Yang
Dec 27, 2005·The Journal of Physical Chemistry. B·Nikolay E PolyakovGenrikh A Tolstikov
Mar 31, 2006·The Journal of Physical Chemistry. B·Nikolay E PolyakovLowell D Kispert
May 1, 2008·Phytotherapy Research : PTR·Marjan Nassiri Asl, Hossein Hosseinzadeh
Sep 2, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yanhua LuXiaoshu Bei
Nov 26, 2009·Mini Reviews in Medicinal Chemistry·T G TolstikovaA O Bryzgalov
Mar 31, 2010·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J-H TuH-H Zhou
Feb 24, 2011·Biomedit︠s︡inskai︠a︡ khimii︠a︡·T G TolstikovaE S Meteleva
Mar 14, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·C J N LaceyJ Ross
Jun 12, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Fatima Zohra DahmaniQiang Zhang
Sep 13, 2012·Journal of Immunotoxicology·Eric G LeeRandle M Gallucci
Mar 11, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fu-Heng YangGuo-Feng Li

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Citations

Sep 10, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yongfei LiChang Yao
Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·A Ligia FocsanLowell D Kispert
Dec 21, 2019·Environmental Science and Pollution Research International·Olga Yu SelyutinaNikolay E Polyakov
Dec 12, 2020·Drug Development and Industrial Pharmacy·Chengying ShenXiaofang Li
Sep 9, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xitong SuPeng Zhang
Mar 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olga Yu SelyutinaNikolay E Polyakov
May 17, 2021·International Journal of Pharmaceutics·Yuyao LiaoXinyuan Shi
Jan 12, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Mohammed Muqtader AhmedMd Khalid Anwer

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