Formulation and evaluation of optimized oxybenzone microsponge gel for topical delivery

Journal of Drug Delivery
Atmaram P PawarAshwin J Mali

Abstract

Background. Oxybenzone, a broad spectrum sunscreen agent widely used in the form of lotion and cream, has been reported to cause skin irritation, dermatitis, and systemic absorption. Aim. The objective of the present study was to formulate oxybenzone loaded microsponge gel for enhanced sun protection factor with reduced toxicity. Material and Method. Microsponge for topical delivery of oxybenzone was successfully prepared by quasiemulsion solvent diffusion method. The effects of ethyl cellulose and dichloromethane were optimized by the 3(2) factorial design. The optimized microsponges were dispersed into the hydrogel and further evaluated. Results. The microsponges were spherical with pore size in the range of 0.10-0.22 µm. The optimized formulation possesses the particle size and entrapment efficiency of 72 ± 0.77 µm and 96.9 ± 0.52%, respectively. The microsponge gel showed the controlled release and was nonirritant to the rat skin. In creep recovery test it had shown highest recovery indicating elasticity. The controlled release of oxybenzone from microsponge and barrier effect of gel result in prolonged retention of oxybenzone with reduced permeation activity. Conclusion. Evaluation study revealed remarkable and enhanced to...Continue Reading

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Citations

Sep 3, 2016·Pharmaceutics·Rajan RajabalayaSheba R David
Nov 21, 2018·Drug Development Research·Gautam SinghviGaurav Gupta
Sep 23, 2018·Progress in Biomaterials·Meenakshi Bhatia, Megha Saini
Sep 25, 2021·Expert Opinion on Drug Delivery·Varalakshmi VelagacherlaUsha Y Nayak

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Methods Mentioned

BETA
differential scanning calorimetry
scanning electron microscopy

Software Mentioned

stress rheological basic
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